KN-93 (hydrochloride)

KN-93 (hydrochloride)
Item number Size Datasheet Manual SDS Delivery time Quantity Price
Cay13864-1 1 mg -

6 - 10 business days*

143.00€
Cay13864-5 5 mg -

6 - 10 business days*

631.00€
Cay13864-10 10 mg -

6 - 10 business days*

1,119.00€
 
KN-93 is a selective inhibitor of Ca2+/calmodulin-dependent kinase type II (CaMKII),... more
Product information "KN-93 (hydrochloride)"
KN-93 is a selective inhibitor of Ca2+/calmodulin-dependent kinase type II (CaMKII), competitively blocking CaM binding to the kinase (Ki = 370 nM). It does not affect the activities of PKA, PKC, MLCK, or Ca2+-phosphodiesterase. It inhibits histamine-induced aminopyrine uptake in parietal cells (IC50 = 300 nM). More recently, KN-93 has been used to implicate roles for CaMKII in Ca2+-induced Ca2+ release in cardiac myocytes, constitutive phosphorylation of 5-lipoxygenase in 3T3 cells, and Ca2+-dependent activation of HIF-1alpha in colon cancer cells.Formal Name: N-[2-[[[3-(4-chlorophenyl)-2-propen-1-yl]methylamino]methyl]phenyl]-N-(2-hydroxyethyl)-4-methoxy-benzenesulfonamide, monohydrochloride. CAS Number: 1956426-56-4. Molecular Formula: C26H29ClN2O4S . HCl. Formula Weight: 537.5. Purity: >98%. Formulation: (Request formulation change), A crystalline solid. Solubility: DMF: 10 mg/ml, DMSO: 10 mg/ml. lambdamax: 252 nm. SMILES: CN(C/C=C/C1=CC=C(Cl)C=C1)CC2=CC=CC=C2N(S(=O)(C3=CC=C(OC)C=C3)=O)CCO.Cl. InChi Code: InChI=1S/C26H29ClN2O4S.ClH/c1-28(17-5-6-21-9-11-23(27)12-10-21)20-22-7-3-4-8-26(22)29(18-19-30)34(31,32)25-15-13-24(33-2)14-16-25,/h3-16,30H,17-20H2,1-2H3,1H/b6-5+,. InChi Key: ATHMCQDBXQEIOK-IPZCTEOASA-N.
Keywords: N-[2-[[[3-(4-chlorophenyl)-2-propen-1-yl]methylamino]methyl]phenyl]-N-(2-hydroxyethyl)-4-methoxy-benzenesulfonamide, monohydrochloride
Supplier: Cayman Chemical
Supplier-Nr: 13864

Properties

Application: CaMKII inhibitor
MW: 537.5 D
Formula: C26H29ClN2O4S . HCl
Purity: >98%
Format: Crystalline Solid

Database Information

CAS : 1956426-56-4| Matching products

Handling & Safety

Storage: -20°C
Shipping: +20°C (International: -20°C)
Signal Word: Warning
GHS Hazard Pictograms:
H Phrases: H315, H319, H335
P Phrases: P261, P264, P271, P280, P302+352, P304+340, P305+351+338, P312, P321, P332+313, P337+313, P362+364, P403+233, P405, P501
Caution
Our products are for laboratory research use only: Not for administration to humans!
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