KN-62

KN-62
Item number Size Datasheet Manual SDS Delivery time Quantity Price
Cay13318-1 1 mg -

6 - 10 business days*

66.00€
Cay13318-5 5 mg -

6 - 10 business days*

146.00€
Cay13318-10 10 mg -

6 - 10 business days*

255.00€
Cay13318-25 25 mg -

6 - 10 business days*

539.00€
 
KN-62 is a selective, cell permeable inhibitor of Ca2+/calmodulin-dependent kinase type II... more
Product information "KN-62"
KN-62 is a selective, cell permeable inhibitor of Ca2+/calmodulin-dependent kinase type II (CaMKII, IC50 = 900 nM). It does not affect the activity of several other kinases when tested at 10 µM. KN-62 also acts as a non-competitive antagonist of the purinergic receptor P2RX7 (IC50 = 15 nM).Formal Name: 5-isoquinolinesulfonic acid, 4-[(2S)-2-[(5-isoquinolinylsulfonyl)methylamino]-3-oxo-3-(4-phenyl-1-piperazinyl)propyl]phenyl ester. CAS Number: 127191-97-3. Molecular Formula: C38H35N5O6S2. Formula Weight: 721.9. Purity: >98%. Formulation: (Request formulation change), A crystalline solid. Solubility: DMF: 30 mg/ml, DMF:PBS (pH 7.2) (1:2): 0.3 mg/ml, DMSO: 30 mg/ml, Ethanol: 1 mg/ml. SMILES: CN([C@@H](CC1=CC=C(OS(=O)(C2=C3C(C=NC=C3)=CC=C2)=O)C=C1)C(N4CCN(C5=CC=CC=C5)CC4)=O)S(C6=CC=CC7=C6C=CN=C7)(=O)=O. InChi Code: InChI=1S/C38H35N5O6S2/c1-41(50(45,46)36-11-5-7-29-26-39-19-17-33(29)36)35(38(44)43-23-21-42(22-24-43)31-9-3-2-4-10-31)25-28-13-15-32(16-14-28)49-51(47,48)37-12-6-8-30-27-40-20-18-34(30)37/h2-20,26-27,35H,21-25H2,1H3/t35-/m0/s1. InChi Key: RJVLFQBBRSMWHX-DHUJRADRSA-N.
Keywords: 5-isoquinolinesulfonic acid, 4-[(2S)-2-[(5-isoquinolinylsulfonyl)methylamino]-3-oxo-3-(4-phenyl-1-piperazinyl)propyl]phenyl ester
Supplier: Cayman Chemical
Supplier-Nr: 13318

Properties

Application: CAMKII inhibitor
MW: 721.9 D
Formula: C38H35N5O6S2
Purity: >98%
Format: Crystalline Solid

Database Information

CAS : 127191-97-3| Matching products
KEGG ID : K04515 | Matching products

Handling & Safety

Storage: -20°C
Shipping: +20°C (International: -20°C)
Caution
Our products are for laboratory research use only: Not for administration to humans!
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