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Item number | Size | Datasheet | Manual | SDS | Delivery time | Quantity | Price |
---|---|---|---|---|---|---|---|
Cay11338-1 | 1 mg | - |
6 - 10 business days* |
77.00€
|
|||
Cay11338-5 | 5 mg | - |
6 - 10 business days* |
279.00€
|
K252a is a staurosporine analog isolated from Nocardiopsis sp. soil fungi that inhibits protein... more
Product information "K252a"
K252a is a staurosporine analog isolated from Nocardiopsis sp. soil fungi that inhibits protein kinase (PK) C, PKA, Ca2+/calmodulin-dependent kinase type II, and phosphorylase kinase with IC50 values of 470, 140, 270, and 1.7 nM, respectively. Because it inhibits neurotrophin receptor tyrosine kinases, K252a at 100-500 nM has been used to suppress trophoblast proliferation and increase apoptosis associated with the disruption of mitochondrial functions in cultured choriocarcinoma cells. Recently, K252a has been shown to inhibit PRK1 (IC50 = 3.2 nM in vitro), a PKC-related kinase that phosphorylates histone H3 at threonine 11 and is involved in androgen-dependent gene expression.Formal Name: 2,3,9S,10R,11,12R-hexahydro-10-hydroxy-9-methyl-1-oxo-9,12-epoxy-1H-diindolo[1,2,3-fg:3',2',1'-kl]pyrrolo[3,4-i][1,6]benzodiazocine-10-carboxylic acid, methyl ester. CAS Number: 99533-80-9. Synonyms: SF 2370. Molecular Formula: C27H21N3O5. Formula Weight: 467.5. Purity: >98%. Formulation: (Request formulation change), A crystalline solid. Solubility: Dichloromethane: 5 mg/ml, DMSO: 50 mg/ml, Methanol: 2 mg/ml. lambdamax: 290 nm. SMILES: O[C@@]1(C(OC)=O)[C@@](O[C@]2([H])C1)(C)N3C4=CC=CC=C4C5=C3C(N2C6=CC=CC=C67)=C7C8=C5CNC8=O. InChi Code: InChI=1S/C27H21N3O5/c1-26-27(33,25(32)34-2)11-18(35-26)29-16-9-5-3-7-13(16)20-21-15(12-28-24(21)31)19-14-8-4-6-10-17(14)30(26)23(19)22(20)29/h3-10,18,33H,11-12H2,1-2H3,(H,28,31)/t18-,26+,27+/m1/s1. InChi Key: KOZFSFOOLUUIGY-SOLYNIJKSA-N. Origin: Bacterium/Nocardiopsis sp..
Keywords: | SF 2370, 2,3,9S,10R,11,12R-hexahydro-10-hydroxy-9-methyl-1-oxo-9,12-epoxy-1H-diindolo[1,2,3-fg:3',2',1'-kl]pyrrolo[3,4-i][1,6]benzodiazocine-10-carboxylic acid, methyl ester |
Supplier: | Cayman Chemical |
Supplier-Nr: | 11338 |
Properties
Application: | Kinase inhibitor |
MW: | 467.5 D |
Formula: | C27H21N3O5 |
Purity: | >98% |
Format: | Crystalline Solid |
Database Information
CAS : | 99533-80-9| Matching products |
KEGG ID : | K00871 | Matching products |
Handling & Safety
Storage: | -20°C |
Shipping: | -20°C (International: -20°C) |
Signal Word: | Warning |
GHS Hazard Pictograms: |
|
H Phrases: | H315, H319, H335 |
P Phrases: | P261, P264, P271, P280, P312, P321, P302+P352, P304+P340, P305+P351+P338, P332+P313, P337+P313, P362+P364, P405, P403+P233, P501 |
Caution
Our products are for laboratory research use only: Not for administration to humans!
Our products are for laboratory research use only: Not for administration to humans!
Information about the product reference will follow.
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