K252a

K252a
Item number Size Datasheet Manual SDS Delivery time Quantity Price
Cay11338-1 1 mg -

6 - 10 business days*

77.00€
Cay11338-5 5 mg -

6 - 10 business days*

279.00€
 
K252a is a staurosporine analog isolated from Nocardiopsis sp. soil fungi that inhibits protein... more
Product information "K252a"
K252a is a staurosporine analog isolated from Nocardiopsis sp. soil fungi that inhibits protein kinase (PK) C, PKA, Ca2+/calmodulin-dependent kinase type II, and phosphorylase kinase with IC50 values of 470, 140, 270, and 1.7 nM, respectively. Because it inhibits neurotrophin receptor tyrosine kinases, K252a at 100-500 nM has been used to suppress trophoblast proliferation and increase apoptosis associated with the disruption of mitochondrial functions in cultured choriocarcinoma cells. Recently, K252a has been shown to inhibit PRK1 (IC50 = 3.2 nM in vitro), a PKC-related kinase that phosphorylates histone H3 at threonine 11 and is involved in androgen-dependent gene expression.Formal Name: 2,3,9S,10R,11,12R-hexahydro-10-hydroxy-9-methyl-1-oxo-9,12-epoxy-1H-diindolo[1,2,3-fg:3',2',1'-kl]pyrrolo[3,4-i][1,6]benzodiazocine-10-carboxylic acid, methyl ester. CAS Number: 99533-80-9. Synonyms: SF 2370. Molecular Formula: C27H21N3O5. Formula Weight: 467.5. Purity: >98%. Formulation: (Request formulation change), A crystalline solid. Solubility: Dichloromethane: 5 mg/ml, DMSO: 50 mg/ml, Methanol: 2 mg/ml. lambdamax: 290 nm. SMILES: O[C@@]1(C(OC)=O)[C@@](O[C@]2([H])C1)(C)N3C4=CC=CC=C4C5=C3C(N2C6=CC=CC=C67)=C7C8=C5CNC8=O. InChi Code: InChI=1S/C27H21N3O5/c1-26-27(33,25(32)34-2)11-18(35-26)29-16-9-5-3-7-13(16)20-21-15(12-28-24(21)31)19-14-8-4-6-10-17(14)30(26)23(19)22(20)29/h3-10,18,33H,11-12H2,1-2H3,(H,28,31)/t18-,26+,27+/m1/s1. InChi Key: KOZFSFOOLUUIGY-SOLYNIJKSA-N. Origin: Bacterium/Nocardiopsis sp..
Keywords: SF 2370, 2,3,9S,10R,11,12R-hexahydro-10-hydroxy-9-methyl-1-oxo-9,12-epoxy-1H-diindolo[1,2,3-fg:3',2',1'-kl]pyrrolo[3,4-i][1,6]benzodiazocine-10-carboxylic acid, methyl ester
Supplier: Cayman Chemical
Supplier-Nr: 11338

Properties

Application: Kinase inhibitor
MW: 467.5 D
Formula: C27H21N3O5
Purity: >98%
Format: Crystalline Solid

Database Information

CAS : 99533-80-9| Matching products
KEGG ID : K00871 | Matching products

Handling & Safety

Storage: -20°C
Shipping: -20°C (International: -20°C)
Signal Word: Warning
GHS Hazard Pictograms:
H Phrases: H315, H319, H335
P Phrases: P261, P264, P271, P280, P312, P321, P302+P352, P304+P340, P305+P351+P338, P332+P313, P337+P313, P362+P364, P405, P403+P233, P501
Caution
Our products are for laboratory research use only: Not for administration to humans!
You will get a certificate here
or to request a certificate of analysis.
Read, write and discuss reviews... more
Customer review for "K252a"
Write a review
or to review a product.
Viewed