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JW 55
JW 55

Item number: Cay16260-5

JW 55 is an inhibitor of the PARP domain of tankyrases (TNKS) 1 and 2 (IC50s = 1.9 and 0.83 µM, respectively). By inhibiting TNKS1/2, JW 55 stabilizes Axin2 and increases degradation of beta-catenin, inhibiting the beta-catenin signaling pathway (IC50 = 470 nM). It has been shown to decrease canonical Wnt signaling...
Keywords: Tankyrase 1/2 Inhibitor IV,...
Application: Wnt/beta-catenin signaling inhibitor, Tankyrase inhibitor
CAS 664993-53-7
MW: 434.5 D
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