JNJ-7777120

JNJ-7777120 is a potent and selective histamine H4 receptor antagonist, with a Ki value of approximately 4 nM against the human, mouse, and rat H4 receptors. Its Ki values for the histamine H1-3 receptors exceed 1 µM, regardless of species, and it has no or negligible effects on a range of other receptors and transporters. JNJ-777120 inhibits mast cell chemotaxis induced by 10 µM histamine (IC50 = 40 nM) and reduces neutrophil influx in mouse peritonitis models (10 mg/kg s.c.). It also impairs eosinophil and lymphocyte influx into airways during allergic airway inflammation.{18910, 18911}Formal Name: (5-chloro-1H-indol-2-yl)(4-methyl-1-piperazinyl)-methanone. CAS Number: 459168-41-3. Molecular Formula: C14H16ClN3O. Formula Weight: 277.8. Purity: >98%. Formulation: (Request formulation change), A crystalline solid. Solubility: DMF: 20 mg/ml, DMF:PBS(pH 7.2)(1:1): 0.5 mg/ml, DMSO: 14 mg/ml, Ethanol: 2 mg/ml. lambdamax: 219, 295 nm. SMILES: ClC1=CC=C(NC(C(N2CCN(C)CC2)=O)=C3)C3=C1. InChi Code: InChI=1S/C14H16ClN3O/c1-17-4-6-18(7-5-17)14(19)13-9-10-8-11(15)2-3-12(10)16-13/h2-3,8-9,16H,4-7H2,1H3. InChi Key: HUQJRYMLJBBEDO-UHFFFAOYSA-N.