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JMJD2E-Strep tagged (human recombinant)

ART NR.: Cay11237-25 (25 µg)
Cay11237-50 (50 µg)
Cay11237-100 (100 µg)

Hersteller: Cayman

Datenblatt

Anwendungen: Demethylation assays

MW: 40 kD

Reinheit: >75%

UniProt ID: B2RXH2
Suche mit UniProt ID

Geninformationen: GeneID 390245

Schlagworte: EC=1.14.11.-, KDM4D-like, JMJD2E, KDM4DL, Lysine-specific demethylase 4D-like, KDM4D-like protein KDM4DL, EC=1.14.11.-, KDM4D-like protein, Lysine-specific demethylase 4D-like

Cay11237-25

25 µg

110 €

Cay11237-50

50 µg

210 €

Cay11237-100

100 µg

397 €

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Bemerkungen: Recombinant N-terminal Strep II-tagged protein expressed in E. coli. Mr: 40.8 kDa. Methylation of lysine residues in core histones plays a critical role in regulating gene expression. Jumonji domain containing 2E (JMJD2E) catalyzes the demethylation of di- and tri-methylated forms of histone H3 at lysine residues 9 and 27 (me 2/3), leading to transcriptional repression and activation, respectively. Like other JmjC protein hydroxylase family members, JMJD2E is an alpha-ketoglutate-dependent Fe (II) oxygenase. Purification of Fe-dependent JmjC family members by IMAC can result in displacement of the catalytic iron and decreased activity, therefore this this Strep-tagged protein is purified by affinity chromatography using Strep-Tactin coated resin. Because of their implication in cancer cell growth, jumonji C domain-containing histone demethylase inhibitors may have the capacity to be anticancer agents.
Image Art Cay11237-50 Cayman JMJD2E-Strep tagged (human recombinant)


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