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Cay11237-50
JMJD2E-​Strep tagged (human recombinant)
Cayman
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50 µg

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210 €

JMJD2E-Strep tagged (human recombinant)


Demethylation assays Erklärungen der Abkürzungen ansehen.

Recombinant N-terminal Strep II-tagged protein expressed in E. coli. Mr: 40.8 kDa. Methylation of lysine residues in core histones plays a critical role in regulating gene expression. Jumonji domain containing 2E (JMJD2E) catalyzes the demethylation of di- and tri-methylated forms of histone H3 at lysine residues 9 and 27 (me 2/3), leading to transcriptional repression and activation, respectively. Like other JmjC protein hydroxylase family members, JMJD2E is an alpha-ketoglutate-dependent Fe (II) oxygenase. Purification of Fe-dependent JmjC family members by IMAC can result in displacement of the catalytic iron and decreased activity, therefore this this Strep-tagged protein is purified by affinity chromatography using Strep-Tactin coated resin. Because of their implication in cancer cell growth, jumonji C domain-containing histone demethylase inhibitors may have the capacity to be anticancer agents.

MW: 40 kD
Purity: >75%

UniProt ID: B2RXH2

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Image Art 11237 Cayman JMJD2E-​Strep tagged (human recombinant)

- Geninformationen GeneID 390245

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Schlagworte:
EC=1.14.11.-​, KDM4D-​like, JMJD2E, KDM4DL, Lysine-​specific demethylase 4D-​like, KDM4D-​like protein KDM4DL, EC=1.14.11.-​, KDM4D-​like protein, Lysine-​specific demethylase 4D-​like

 

 

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