JMJD2A (human, recombinant, His-tagged)

JMJD2A (human, recombinant, His-tagged)
Item number Size Datasheet Manual SDS Delivery time Quantity Price
Cay10336-100 100 µg -

6 - 10 business days*

642.00€
 
Jumonji Domain Containing 2A (JMJD2A) is a lysine-specific demethylase that catalyzes the... more
Product information "JMJD2A (human, recombinant, His-tagged)"
Jumonji Domain Containing 2A (JMJD2A) is a lysine-specific demethylase that catalyzes the demethylation of histone H3 at lysine residues 9 and 36 and histone H1.4 at lysine residue 26. It is composed of the JmjN N-terminal domain, JmjC catalytic domain, two plant homeodomains (PHDs), and two tudor domains that recognize the methylated histones. JMJD2A is ubiquitously expressed and localized to the nucleus. It is involved in the regulation of gene expression in a context-dependent manner, having roles in both transcriptional silencing and activation of androgen and estrogen receptors (ERs). Knockdown of JMJD2A inhibits the proliferation of ER-positive and -negative breast cancer cells and induces apoptosis and cell cycle arrest in colon cancer cells. It is overexpressed in various cancers, including prostate, lung, and colorectal, as well as glioblastomas and endometrial carcinomas, and is associated with higher tumor grade and decreased disease-free survival in breast cancer. Cayman's JMJD2A (human, recombinant) can be used for ELISA and Western blot (WB) applications.Synonyms: Lysine (K)-specific Demethylase 4A, JHDM3A, Jumonji Domain Containing 2A, KDM4A. Purity: >95% estimated by SDS-PAGE. Source: Recombinant N-terminal His-tagged protein expressed in E. coli. Amino Acids: 1-350 (C-terminal truncation). MW: 43 kDa. Formulation: (Request formulation change), 50 mM HEPES, pH 7.4, containing 150 mM sodium chloride and 20% glycerol. Host: E. coli. Applications: ELISA, WB. UniProt Accession #: O75164.
Keywords: KDM4A, JHDM3A, Lysine-specific demethylase 4A, Lysine-specific demethylase 4A, Jumonji domain-containing protein 2A, Jumonji domain-containing protein 2A, JmjC domain-containing histone demethylation protein 3A, JmjC domain-containing histone demethylatio
Supplier: Cayman Chemical
Supplier-Nr: 10336

Properties

Application: Enzyme activity
Conjugate: No
MW: 43 kD
Purity: >95% estimated by SDS-PAGE
Format: Solution

Handling & Safety

Storage: -80°C
Shipping: -80°C (International: -80°C)
Signal Word: Warning
GHS Hazard Pictograms:
H Phrases: H316, H319
P Phrases: P264, P280, P305+351+338, P332+313, P337+313
Caution
Our products are for laboratory research use only: Not for administration to humans!
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