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Cay11299-25
JMJD2A-​Strep tagged (human recombinant)
Cayman
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25 µg

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110 €

JMJD2A-Strep tagged (human recombinant)


Demethylation assays Erklärungen der Abkürzungen ansehen.

Recombinant N-terminal Strep II-tagged protein expressed in E. coli. Mr: 42.7 kDa. Methylation of lysine residues of core histones plays a critical role in the regulation of gene expression. Jumonji domain containing 2A (JMJD2A) is the first reported trimethyllysine-specific histone demethylase. It catalyzes the demethylation of tri- and di-methylated forms of histone H3 at lysine residues 9 and 36. Like other JmjC protein hydroxylase family members, JMJD2A is an alpha-ketoglutate-dependent Fe (II) oxygenase. Purification of Fe-dependent JmjC family members by IMAC can result in displacement of the catalytic iron and decreased activity, therefore this Strep-tagged protein is purified by affinity chromatography using Strep-Tactin coated resin. JMJD2A's transcriptional function appears to depend on protein associations, as it is implicated in both transcriptional silencing and upregulation of the androgen receptor-dependent genes. Because of their implication in cancer cell growth, jumonji C domain-containing histone demethylases may be drug discovery targets for therapeutic intervention.

MW: 42 kD
Purity: >95%

UniProt ID: O75164

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Image Art 11299 Cayman JMJD2A-​Strep tagged (human recombinant)

- Geninformationen GeneID 9682

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Products for: JMJD2, JHDM3 - jumonji domain-containing protein 2 [EC:1.14.11.-]



Schlagworte:
KDM4A, JHDM3A, EC=1.14.11.-​, Lysine-​specific demethylase 4A, Jumonji domain-​containing protein 2A, JmjC domain-​containing histone demethylation protein 3A

 

 

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