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JMJD2A-Strep tagged (human recombinant)

ART NR.: Cay11299-25 (25 µg)
Cay11299-50 (50 µg)
Cay11299-100 (100 µg)

Hersteller: Cayman


Anwendungen: Demethylation assays

MW: 42 kD

Reinheit: >95%

Lagerung: -80°C

Versand: -20°C

UniProt ID: O75164 | Suche mit UniProt ID

Gene ID: Gene ID 9682 | Suche mit Gene ID

KEGG ID: K06709 | Suche mit KEGG ID

Schlagworte: KDM4A, JHDM3A, EC=1.14.11.-, Lysine-specific demethylase 4A, Jumonji domain-containing protein 2A, JmjC domain-containing histone demethylation protein 3A


25 µg

116 €


50 µg

217 €


100 µg

426 €

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Bemerkungen: Recombinant N-terminal Strep II-tagged protein expressed in E. coli. Mr: 42.7 kDa. Methylation of lysine residues of core histones plays a critical role in the regulation of gene expression. Jumonji domain containing 2A (JMJD2A) is the first reported trimethyllysine-specific histone demethylase. It catalyzes the demethylation of tri- and di-methylated forms of histone H3 at lysine residues 9 and 36. Like other JmjC protein hydroxylase family members, JMJD2A is an alpha-ketoglutate-dependent Fe (II) oxygenase. Purification of Fe-dependent JmjC family members by IMAC can result in displacement of the catalytic iron and decreased activity, therefore this Strep-tagged protein is purified by affinity chromatography using Strep-Tactin coated resin. JMJD2A's transcriptional function appears to depend on protein associations, as it is implicated in both transcriptional silencing and upregulation of the androgen receptor-dependent genes. Because of their implication in cancer cell growth, jumonji C domain-containing histone demethylases may be drug discovery targets for therapeutic intervention.
Image Art Cay11299-25 Cayman JMJD2A-Strep tagged (human recombinant)

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