JMJD2A-Strep tagged (human recombinant), Cayman, Cay11299-100

Treffer 1

ART-NR	PRODUKT	HERSTELLER	MENGE	PREIS
Cay11299-100	JMJD2A-Strep tagged (human recombinant)	Cayman	100 µg Buy Bulk	397 €
Demethylation assays Recombinant N-terminal Strep II-tagged protein expressed in E. coli. Mr: 42.7 kDa. Methylation of lysine residues of core histones plays a critical role in the regulation of gene expression. Jumonji domain containing 2A (JMJD2A) is the first reported trimethyllysine-specific histone demethylase. It catalyzes the demethylation of tri- and di-methylated forms of histone H3 at lysine residues 9 and 36. Like other JmjC protein hydroxylase family members, JMJD2A is an alpha-ketoglutate-dependent Fe (II) oxygenase. Purification of Fe-dependent JmjC family members by IMAC can result in displacement of the catalytic iron and decreased activity, therefore this Strep-tagged protein is purified by affinity chromatography using Strep-Tactin coated resin. JMJD2A's transcriptional function appears to depend on protein associations, as it is implicated in both transcriptional silencing and upregulation of the androgen receptor-dependent genes. Because of their implication in cancer cell growth, jumonji C domain-containing histone demethylases may be drug discovery targets for therapeutic intervention. MW: 42 kD Purity: >95% UniProt ID: O75164 Loading ... - Geninformationen GeneID 9682 Weitere Produkte für dieses Protein: Antibodies Anti-JMJD2A, Kat #: A300-860A Anti-JMJD2A, Kat #: A300-861A Anti-JMJD2A (IHC), Kat #: IHC-00188 Anti-JMJD2A (N-term), Kat #: WA-AP1046a Anti-JMJD2A, NT (JMJD2A, JHDM3A, JMJD2, KIAA0677, Lysine-specific Demethylase 4A, JmjC Domain-containing Histone Demethylation Protein 3A, Jumonji domain-Containing Protein 2A, KDM4A), Kat #: J7876-45D.100 Anti-Jumonji Domain Containing 2A, Kat #: Cay10382-1 Anti-Jumonji Domain Containing 2A (JMJD2A, JHDM3A, KIAA0, Kat #: J7876-45.50 Anti-Jumonji Domain Containing 2A (JMJD2A, JMJD2, JmjC Domain Containing Histone Demethylation Protein 3A, Jumonji C Domain Containing Histone Demethylase 3A, JHDM3A, KDM4A, KIAA0677), Kat #: J7876-45F.100 Anti-KDM4A (C), Kat #: AC-R0229-2 Anti-KDM4A, clone 5H1, Kat #: Pro-30087 more Enzymes & Proteins JMJD2A(KDM4A) Active Human Recombinant Protein (1-350), Kat #: BPS-50123 JMJD2A, human recombinant, Kat #: Cay10336-25 JMJD2A, human recombinant, Kat #: Cay10336-50 JMJD2A, human recombinant, Kat #: Cay10336-100 JMJD2A-Strep tagged (human recombinant), Kat #: Cay11299-50 JMJD2A-Strep tagged (human recombinant), Kat #: Cay11299-25 siRNA KDM4A predesign siRNA, Kat #: WA-RI12865 ELISA and Assay Kits JMJD2A Homogeneous Assay kit, Kat #: BPS-50413 JMJD2A Inhibitor Screening Assay Kit, Kat #: Cay700360-96 Peptides JMJD2A Antibody (N-term) Blocking Peptide, Kat #: WA-BP1046a Phospho-JMJD2A-Y547 Antibody Blocking Peptide, Kat #: WA-BP3726a Products for: JMJD2, JHDM3 - jumonji domain-containing protein 2 [EC:1.14.11.-] Antibodies (34) Buffers/Solutions (5) Chemicals & More (6) ELISA and Assay Kits (7) Enzymes & Proteins (16) Peptides (7) Plasmids/Vectors (1) Primers (2) siRNA (3) Schlagworte: KDM4A, JHDM3A, EC=1.14.11.-, Lysine-specific demethylase 4A, Jumonji domain-containing protein 2A, JmjC domain-containing histone demethylation protein 3A