JAK/STAT pathway ISRE reporter cell line, 1,5x 10(6) cells

Item number Size Datasheet Manual SDS Delivery time Quantity Price
BPS-60510 2 vials (2 vials) - -

3 - 15 business days*

3,241.00€
 
The ISRE Reporter - HEK293 Cell Line is designed for monitoring the activity of the JAK/STAT... more
Product information "JAK/STAT pathway ISRE reporter cell line, 1,5x 10(6) cells"
The ISRE Reporter - HEK293 Cell Line is designed for monitoring the activity of the JAK/STAT signaling pathway. The JAK (Janus kinase) /STAT (Signal Transducer and Activator of Transcription) pathway is activated by various cytokines and growth factors and plays a critical role in cell growth, hematopoiesis, and immune response. In mammals, there are four JAKs (JAK1, JAK2, JAK3 and TYK2) and seven STAT proteins. Binding of Interferon alpha to its receptor leads to the activation of JAK1 and TYK2, which in turn phosphorylate and activate STAT1 and STAT2. The phosphorylated STAT1 and 2 form a heterodimer and bind to IRF9/p48, forming a protein complex known as ISGF3. This complex translocates to the nucleus and binds to the ISRE (Interferon Stimulated Response Element) in the promoter region thereby promoting transcription of interferon-inducible genes. The ISRE Reporter - HEK293 Cell Line contains the firefly luciferase gene under the control of ISRE stably integrated into HEK293 cells. This cell line is validated for the response to stimulation with interferon Alpha A and to treatment with JAK inhibitor.
Keywords: JAK reporter, STAT reporter, ISRE cell line,
Supplier: BPS Bioscience
Supplier-Nr: 60510

Properties

Application: JAK/STAT pathway activity monitoring
Host: HEK293

Handling & Safety

Storage: Liquid nitrogen
Shipping: -80°C (International: -80°C)
Caution
Our products are for laboratory research use only: Not for administration to humans!
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