Physical exertion and exercise are the primary defenses against obesity, insulin resistance, and diabetes. The transcriptional co-activator peroxisome proliferator-activated receptor C coactivator 1alpha (PGC-1alpha), regulates mitochondrial biogenesis and function. Expression of the membrane protein Fibronectin...

(1R,3S)-3-Aminocyclopentane carboxylic acid is a synthetic intermediate useful for pharmaceutical synthesis.Formal Name: (1R,3S)-3-amino-cyclopentanecarboxylic acid. CAS Number: 71830-08-5. Molecular Formula: C6H11NO2. Formula Weight: 129.2. Purity: >95%. Formulation: (Request formulation change), A neat oil....

Actinomycin D is a cyclic polypeptide-containing antibiotic that binds to DNA and blocks transcription. It binds to pre-melted double-stranded DNA in transcription bubbles and once bound is slow to dissociate. DNA in transcriptionally hyperactive cancer cells efficiently and rapidly bind actinomycin D at low...

Indinavir is an HIV-1 protease inhibitor (Ki = 0.358 nM). It is selective for HIV-1 protease over HIV-2 protease (Ki = 3.316 nM), as well as human cathepsin D, porcine pepsin, bovine chymosin, human plasma renin, Factor Xa, and elastase at 10 µM. It is also selective for wild-type HIV-1 protease over the protease...