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Protein function: Plays a critical role in endothelial cell capillary morphogenesis. [The UniProt Consortium]

BRD4 is a member of the BET (bromo domain and extra terminal domain) family, along with BRD2, BRD3 and BRDT. BRD4 is required to form the transcriptionally active P-TEFb complex by displacing negative regulators such as HEXIM1 and 7SKsnRNA complex from P-TEFb, thereby transforming it into an active form that can...

CrkL is a 39kD adaptor protein, originally cloned in proximity to the BCR gene on chromosome 22, which has a key regulatory role in hematopoietic cells. CrkL has one SH2 and two SH3 domains, with 60% homology to CrkII (1). Structurally, the amino-terminal SH3 domain of CrkL has been shown to bind proteins such as...

Huntingtin is a disease gene linked to Huntington's disease, a neurodegenerative disorder characterized by loss of striatal neurons. This is thought to be caused by an expanded, unstable trinucleotide repeat in the huntingtin gene, which translates as a polyglutamine repeat in the protein product. A fairly broad...

Rab GTPase effector involved in the late steps of regulated exocytosis, both in endocrine and exocrine cells. Acts as a potential RAB3B effector protein in epithelial cells. Source: Recombinant protein corresponding to aa1-315 from human RPH3AL, fused to His-SUMO-Tag at N-terminal, expressed in E. coli. Molecular...

Adapter protein implicated in the regulation of a large spectrum of both general and specialized signaling pathways. Binds to a large number of partners, usually by recognition of a phosphoserine or phosphothreonine motif. Binding generally results in the modulation of the activity of the binding partner. Source:...

Myelin basic protein (MBP) is a single-chain, flexible polypeptide of ~18.5kD existing in its natural environment as an extrinsic and loosely bound component of the cytoplasmic portion of the myelin membrane sandwich. Ultrastructural immunocytochemistry with anti-myelin basic protein has shown that MBP is localized...

Lymphatic vascular endothelial hyaluronan receptor-1 (LYVE-1), a selective marker of the lymphatic endothelium, is a surface endocytic receptor for hyaluronan (HA), which is an extracellular glycosaminoglycan involved in cell adhesion and migration. HA is widely expressed on leukocytes, dendritic cells, and tumor...

Involved in DNA repair and RecF pathway recombination. Source: Recombinant protein corresponding to aa1-242 from E. coli RecO, fused to His-SUMO-Tag at N-terminal, expressed in E. coli. Molecular Weight: ~43.4kD, AA Sequence:...

Mouse recombinant Interleukin-22 Antagonist produced in E.coli is a single, non-glycosylated homodimeric polypeptide chain containing 147 amino acids and having a total molecular mass of 16.7 KDa. IL-22 is a member of the IL-10 family of regulatory cytokines.Members of this family share partial homology in their...