Induces activation of NF-kappa-B and stimulates production of the proinflammatory chemokine IL-8. Proinflammatory cytokine favoring Th2-type immune responses. (www.uniprot.org) Produced in E.coli as a homodimeric, non-glycosylated polypeptide chain containing 146 amino acids.
Menge: 25 µg
Preis: 170 €
UniProt ID: Q9H293 (Protein knowledgebase)
IL-25, IL-17E, IL17E, IL25, Interleukin-25, Interleukin-17E.
IL-25 also called IL-17E cytokine has a sequence similarity with IL17. IL-17E indluces NF-kappaB activation, and stimulates the production of IL-8. IL17E and IL17B are ligands for the cytokine receptor IL17BR. IL-25 is a proinflammatory cytokine favoring Th2-type immune response. The upregulation of costimulation-induced IL-17E receptors and release of cytokines and chemokines from IL-17E treated costimulated Th cells are differentially regulated by intracellular JNK, p38 MAPK and NF-kappaB activity. Blocking Iinterleukin-25 prevents airway hyperresponsiveness, a critical feature of clinical asthma. IL25 produced by innate effector eosinophils and basophils increase the allergic inflammation by enhancing the maintenance and functions of TSLP-DC activated adaptive Th2 memory cells. Over expression of IL-25 up-regulates gene expression of Th2 cytokines and induces growth retardation, jaundice, and multiorgan inflammation in a transgenic mouse model. IL-25 contributes to the induction and maintenance of eosinophilic inflammation by acting on lung fibroblasts which supports the fact that IL-17E is an important factor in asthma pathophysiology. IL-17E operates by amplifying TH2 cell-mediated allergic airway inflammation but doesn’t induce allergic inflammation in vivo.
Interleukin-17E Human Recombinant produced in E.Coli is a homodimeric, non-glycosylated polypeptide chain containing 146 amino acids and having a molecular mass of 33.7 kDa.
The IL-25 Human is purified by proprietary chromatographic techniques.
Sterile Filtered White lyophilized (freeze-dried) powder.
Lyophilized from a concentrated (1mg/ml) solution containing no additives.
It is recommended to reconstitute the lyophilized Interleukin Human IL25 in sterile 10mM HCL not less than 100µg/ml, which can then be further diluted to other aqueous solutions.
Lyophilized Interleukin Human IL17E although stable at room temperature for 3 weeks, should be stored desiccated below -18°C. Upon reconstitution Human IL-25 should be stored at 4°C between
2-7 days and for future use below -18°C.
For long term storage it is recommended to add a carrier protein (0.1% HSA or BSA).
Please prevent freeze-thaw cycles.
Greater than 95.0% as determined by(a) Analysis by RP-HPLC.
(b) Analysis by SDS-PAGE.
Amino acid sequence
MYSHWPSCCP SKGQDTSEEL LRWSTVPVPP LEPARPNRHP ESCRASEDGP LNSRAISPWR YELDRDLNRL PQDLYHARCL CPHCVSLQTG SHMDPRGNSE LLYHNQTVFY RRPCHGEKGT HKGYCLERRL YRVSLACVCV RPRVMG.
Weitere Produkte für dieses Protein:
- Anti-Human IL-17E Biotin Conjugated, clone 11K8B1, Biotin Conjugated, Kat #: 209-306-C58
- Anti-Human IL-17E, clone 11K8B1, Kat #: 209-301-C58
- Anti-Human IL-17E, clone 11K8B1, Kat #: 209-301-C58S
- Anti-IL-17E, clone 68C1039.2, Kat #: IMG-323A
- Anti-IL25 (C), Kat #: AC-R0068-2
- Anti-IL25 (C), clone 5D10, Kat #: AC-M0011-1
- Anti-IL25 (Center), Kat #: WA-AP14661c.80
- Anti-IL25 (Center), Kat #: WA-AP14661c
- Anti-IL25 (N), Kat #: AC-R0068-1
- Anti-IL25 (vPair(TM)), Kat #: AC-R0068-vp
Chemicals & More
Products for: IL17E, IL25 - interleukin 17E