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Interleukin-17, His Tag, human recombinant (rHuIL-17-His)
Product information "Interleukin-17, His Tag, human recombinant (rHuIL-17-His)"
Induces stromal cells to produce proinflammatory and hematopoietic cytokines. Enhances the surface expression of the intracellular adhesion molecule-1 (ICAM-1) in fibroblasts. (www.uniprot.org) Human recombinant Interleukin-17A produced in E.coli is a single, non-glycosylated, polypeptide chain containing 132 amino acids (fragment 24-155) having a molecular weight of 21.5kDa and fused with a 4.5kDa amino-terminal hexahistidine tag. IL-17 is a proinflammatory cytokine produced by activated T-cells. IL-17 regulates the activities of NF-kappaB and mitogen-activated protein kinases. Interleukin-17 can stimulate the expression of IL-6 and cyclooxygenase-2 (PTGS2/COX-2), as well as enhance the production of nitric oxide (NO). High levels of IL-17 are associated with several chronic inflammatory diseases including rheumatoid arthritis, psoriasis and multiple sclerosis.
This website uses cookies, which are necessary for the technical operation of the website and are always set. Other cookies, which increase the usability of this website, serve for direct advertising or simplify interaction with other websites and social networks, will only be used with your consent.
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