213 products were found matching "I7663"!

Interleukin-2 (IL-2) is a potent lymphoid cell growth factor which primarily acts on T-cells. Source: Recombinant protein corresponding to mouse IL-2, expressed in E. coli. , Molecular Weight: ~17.2kD (149aa sequence) , Activity: 5 x 10e6units/mg, , Applications:, Suitable for use in Functional Assays. Other...

One of the most potent pro-inflammatory mediators is the early-acting cytokine interleukin-1 (IL-1), whose actions are regulated by the structurally related IL-1 receptor antagonist (IL-1 RA). IL-1 RA is a competitive IL-1 inhibitor and a powerful anti-inflammatory agent. Also, Several autoimmune and inflammatory...

CD123 is the 70kD transmembrane a chain of the IL-3 receptor. Alone, CD123 binds IL-3 with low affinity, when CD123 associates with CDw131 (common B chain), it binds IL-3 with high affinity. CD123 does not transduce intracellular signals upon binding IL-3 and requires the B chain for this function. CD123 is...

Sequence (linear): Leu-Lys-Glu-Lys-Asn-Leu-Tyr-Leu-Ser-Cys-Val-Leu-Lys-Asp-Asp-Lys-Pro-Thr-Leu-Gln-Leu-Glu-Ser-Val-Asp-Pro-Lys-Asn-Tyr-Pro, Storage and Stability: Lyophilized powder may be stored at 4°C for short-term only. Stable for 12 months at -20°C. Reconstitute to nominal volume (see reconstitution...

Interleukin 33 (IL-33) is a 32kD proinflammatory cytokine that may also regulate gene transcription in producer cells. IL-33 is structurally related to IL-1, which induces helper T cells to produce type 2 cytokines and acts through the receptor IL1RL-1 (IL1 receptor-like-1), which is known also as ST2. Binding of...

IL-1beta, also known as IL1F2, is a prototypical member of the IL-1 superfamily. It is produced by a wide variety of cells in response to inflammatory agents, infections, or microbial endotoxins. The biological activity of IL-1beta is mediated by the heterodimeric receptor complex containing IL-1 R1 (IL-1 RI) and...

CD121a is the 80kD type I interleukin-1 receptor. CD121a is weakly expressed on most cells and tissues including T lymphocytes, thymocytes, epithelial cells and dendritic cells, with stronger expression reported on fibroblasts. The ligands for CD121a are the interleukin-1 (IL-1) family members, IL-1 alpha, IL-1 beta...

The IL-1ra3 belongs to the IL-1 system which includes two agonists (IL-1a and IL-1b), converting enzymes, antagonistic two receptors (IL-1 R1 and IL-1 RII) and the IL-1 receptor accessory protein. Applications: Suitable for use in ELISA, Western Blots, immunohistology on frozen sections and immunoassays. Other...

The g chain of the high affinity functional human IL-2 receptor complex belongs to the hematopoietin receptor family. IL-2 Rg is a 369aa protein consisting of a 22aa signal sequence, a 232aa extracellular domain, a 29aa transmembrane domain and an 86aa cytoplasmic domain. Although IL-2 Rg by itself does not bind...

IL3RA (CD123) is a member of the immunoglobulin superfamily that is expressed on hematopoietic progenitors, basophils, mast cells, and megakaryocytes. This transmembrane glycoprotein can bind IL3 with low affinity but cannot transduce signals without association with additional protein partners. CD123 can complex...

Interleukin 1 alpha (IL-1 alpha) is synthesized as a 33kD precursor that mainly remains intracellular. Cleavage by calpain in keratinocytes, epithelial cells and endotoxin-stimulated peripheral blood mononuclear cells produces a 112aa, 16kD propeptide and a 159aa, 17kD mature protein. A nuclear localization site in...

IL-1alpha is a non-secreted proinflammatory cytokine produced in a variety of cells including monocytes, tissue macrophages, keratinocytes and other epithelial cells. Both IL-1alpha and IL-1beta binds to the same receptor and has similar if not identical biological properties. These cytokines have a broad range of...