25 products were found matching "87410.2"!

TTNPB is an analog of retinoic acid (Cay-11017) that potently and selectively activates retinoic acid receptors (EC50s = 21, 4, and 2.4 nM for RARalpha, RARbeta, and RARgamma, respectively). It does not act on retinoid X receptors and weakly agonizes farnesoid X receptor (EC50 > 1 µM). TTNPB is used to study RAR...

1'-hydroxy Bufuralol is a metabolite of bufuralol (Cay-17794). Bufuralol is metabolized by the cytochrome P450 isoforms 2D1 and 2D2 (CYP2D1/2), therefore, quantification of the bufuralol metabolite, 1'-hydroxy bufuralol, can be used to determine CYP2D1/2 enzyme activity in humans and rats.Formal Name:...

CGP 42112 is an angiotensin II type 2 (AT2) receptor agonist. It binds to AT2 receptors (Ki = 0.24 nM) and inhibits cGMP production and tyrosine hydroxylase activity in primary porcine adrenal medullary cells when used at concentrations ranging from 0.001 to 1 µM, effects that can be blocked by the AT2 receptor...

BD 1063 is an antagonist of sigma-1 (sigma1) receptors (Ki = 9 nM). It is selective for sigma1 receptors over sigma2 (Ki = 449 nM) and serotonin 5-HT2 receptors (Ki = 2,552 nM), as well as opioid, dopamine D2, PCP, serotonin 5-HT1, alpha1-, alpha2-, and beta-adrenergic receptors where it has Ki values of greater...

Neocuproine is a phenanthroline compound that is used as a chelating agent in a wide array of transition metal-catalyzed reactions. It can also be used in the synthesis of aryl ketones.Formal Name: 2,9-dimethyl-1,10-phenanthroline. CAS Number: 484-11-7. Synonyms: NSC 4280, VUF 7738. Molecular Formula: C14H12N2....

Trofosfamide is a nitrogen mustard alkylating agent and a derivative of cyclophosphamide (Cay-13849) that has antiproliferative activities. It increases the number of micronucleated polychromatic red blood cells isolated from mouse bone marrow, indicating cytogenetic activity, when administered at doses of 40, 80,...

1-Palmitoyl-3-stearoyl-rac-glycerol is a diacylglycerol that contains palmitic acid (Cay-10006627) at the sn-1 position and stearic acid (Cay-10011298) at the sn-3 position. It has been found in palm-based diacylglycerols produced from palm stearin, palm mid fraction, palm oil, and palm olein, as well as in wheat...

E3 ubiquitin-protein ligase that mediates ubiquitination of p53/TP53, leading to its degradation by the proteasome. Inhibits p53/TP53- and p73/TP73-mediated cell cycle arrest and apoptosis by binding its transcriptional activation domain. Also acts as a ubiquitin ligase E3 toward itself and ARRB1. Permits the...

Buffer: PBS and 1M Urea, pH 7.4.

VL422 is an ionizable cationic lipid. It has been used in the generation of lipid nanoparticles (LNPs) for the delivery of CRISPR complementary single-guide RNA (sgRNA) and Cas9 mRNA for gene editing in vitro and in vivo. LNPs containing VL422 and encapsulating Cas9 mRNA and sgRNA targeting the gene encoding...

Primers are provided as a 40 µl solution containing both primers at a final concentration of 50 µM in 10 mM Tris-HCl (pH 7.5), 0.1 mM EDTA. Dilute with water as needed prior to use. This amount is sufficient for 1000 x 20µl PCR reactions assuming a final primer concentration of 0.1 µM. Add cDNA template....

Primers are provided as a 40 µl solution containing both primers at a final concentration of 50 µM in 10 mM Tris-HCl (pH 7.5), 0.1 mM EDTA. Dilute with water as needed prior to use. This amount is sufficient for 1000 x 20µl PCR reactions assuming a final primer concentration of 0.1 µM. Add cDNA template....