Indomethacin N-octyl amide

Indomethacin N-octyl amide
Item number Size Datasheet Manual SDS Delivery time Quantity Price
Cay70273-1 1 mg -

6 - 10 business days*

34.00€
Cay70273-5 5 mg -

6 - 10 business days*

143.00€
Cay70273-10 10 mg -

6 - 10 business days*

249.00€
Cay70273-50 50 mg -

6 - 10 business days*

1,081.00€
 
Indomethacin is a potent but non-selective inhibitor of both COX-1 and COX-2 in sheep and humans.... more
Product information "Indomethacin N-octyl amide"
Indomethacin is a potent but non-selective inhibitor of both COX-1 and COX-2 in sheep and humans. Structurally, indomethacin is a substituted indole acetic acid, wherein the carboxylate can be derivitized as an ester or amide. These derivatives show enhanced selectivity for the COX-2 isoform. For example, the IC50 values of indomethacin N-octyl amide for the inhibition of ovine COX-1 and human recombinant COX-2 are 66 µM and 40 nM, respectively, making it 1,650 times more potent as an inhibitor of COX-2 than COX-1. While indomethacin itself has an IC50 of 0.05 µM for the inhibition of COX-2, it also inhibits COX-1 with a corresponding IC50 of 0.67 µM.Formal Name: N-octyl-1-(4-chlorobenzoyl)-5-methoxy-1H-indole-3-acetamide. CAS Number: 282728-65-8. Molecular Formula: C27H33ClN2O3. Formula Weight: 469.0. Purity: >98%. Formulation: (Request formulation change), A crystalline solid. Solubility: DMF: 27 mg/ml, DMF:PBS (5:2): 8 mg/ml, Ethanol: 2 mg/ml. lambdamax: 230, 260, 319 nm. SMILES: ClC1=CC=C(C(N2C(C=CC(OC)=C3)=C3C(CC(N([H])CCCCCCCC)=O)=C2C)=O)C=C1. InChi Code: InChI=1S/C27H33ClN2O3/c1-4-5-6-7-8-9-16-29-26(31)18-23-19(2)30(25-15-14-22(33-3)17-24(23)25)27(32)20-10-12-21(28)13-11-20/h10-15,17H,4-9,16,18H2,1-3H3,(H,29,31). InChi Key: DBWILLAXKDUAPA-UHFFFAOYSA-N.
Keywords: N-octyl-1-(4-chlorobenzoyl)-5-methoxy-1H-indole-3-acetamide
Supplier: Cayman Chemical
Supplier-Nr: 70273

Properties

Application: COX-2 inhibitor
MW: 469 D
Formula: C27H33ClN2O3
Purity: >98%
Format: Crystalline Solid

Database Information

CAS : 282728-65-8| Matching products
KEGG ID : K11987 | Matching products

Handling & Safety

Storage: -20°C
Shipping: +20°C (International: -20°C)
Caution
Our products are for laboratory research use only: Not for administration to humans!
You will get a certificate here
or to request a certificate of analysis.
Read, write and discuss reviews... more
Customer review for "Indomethacin N-octyl amide"
Write a review
or to review a product.
Viewed