15 products were found matching "Cay15150"!

Indinavir is an HIV-1 protease inhibitor (Ki = 0.358 nM). It is selective for HIV-1 protease over HIV-2 protease (Ki = 3.316 nM), as well as human cathepsin D, porcine pepsin, bovine chymosin, human plasma renin, Factor Xa, and elastase at 10 µM. It is also selective for wild-type HIV-1 protease over the protease...

Buphedrone (hydrochloride) (Cay-11283) is a substituted cathinone characterized by an ethyl group at the alpha position and an N-terminal methyl group. This compound has been identified in products sold as stimulants. 4-fluoro Buphedrone is a para-fluoro analog of buphedrone. Its biological and toxicological...

XLR11 (Cay-11565) is a synthetic cannabinoid (CB) with a tetramethylcyclopropyl group, which reportedly confers selectivity for the peripheral CB2 receptor over the central CB1 receptor. FAB-144 is an analog of XLR11 that has an indazole, rather than an indole group. The physiological and toxicological properties of...

Boldenone is an anabolic androgenic steroid and synthetic derivative of testosterone that was originally developed for veterinary use. It can increase nitrogen retention, protein synthesis, and appetite, and also stimulates the release of erythropoietin in the kidneys. Boldenone cypionate was synthesized as an ester...

3,4-MDMA (Cay-13971) is a euphoric entactogen that is regulated as a Schedule I compound in the United States. 3,4-EDMA is an analog of 3,4-MDMA that stimulates the release of serotonin (Cay-14332) and dopamine from rat brain synaptosomes at 1 µM. This product is intended for forensic and research...

Nevirapine is a non-nucleoside reverse transcriptase inhibitor (NNRTI). It binds to HIV-1 reverse transcriptase and inhibits RNA plus-strand initiation (IC50 = 0.45 µM). Nevirapine prevents seroconversion and viremia in a chimpanzee model of HIV-1 infection. Formulations containing nevirapine have been used in...

Pentacosanoic acid is a 25-carbon, fully saturated long-chain fatty acid found in plant lipids.Formal Name: pentacosanoic acid. CAS Number: 506-38-7. Synonyms: FA 25:0, Hyenic Acid, NSC 89289. Molecular Formula: C25H50O2. Formula Weight: 382.7. Purity: >98%. Formulation: (Request formulation change), A crystalline...

Nelfinavir is an orally bioavailable inhibitor of the HIV-1 protease (Ki =2 nM). It demonstrates anti-cancer activity, selectively preventing the growth of HER2-positive breast cancer cells in vitro by inhibiting Hsp90 (IC50 = 3.1 µM). Formulations containing nelfinavir have been used in combination with HIV reverse...

1,2-Dioleyloxy-3-dimethylamino-propane (DODMA) is an ionizable cationic lipid (pKa = 6.59 in a TNS binding assay) that contains the unsaturated long-chain (18:1) oleic acid inserted at both the sn-1 and sn-2 positions. It has been used in the composition of liposomes formulated as stable nucleic acid lipid particles...

Abiraterone acetate is an inhibitor of the cytochrome P450 (CYP) isoform CYP17A1 (IC50s = 17 and 18 nM for inhibition of C17,20-lyase and 17alpha-hydroxylase activities, respectively). It is also a prodrug form of abiraterone (Cay-9002768). Abiraterone acetate reduces plasma testosterone levels, increases plasma...

NADPH oxidase 1 (NOX1) generates reactive oxygen species (ROS) in colon epithelial cells that interacts with both pathogenic and normal bacteria. Excess ROS production, however, is associated with damage to the intestinal mucosa, inflammatory bowel disease, and prostate cancer. ML-090 is the first identified...

Corticotropin-releasing hormone (CRH) secreted from the hypothalamus is the major regulator of pituitary corticotropin-release and consequent glucocorticoid secretion. Antalarmin is a selective, nonpeptide antagonist of the CRH receptor 1 (Ki = 1 nM) that, consequently, reduces the release of corticotropin in...