ITPA, aa1-194, Recombinant, Human (Inosine Triphosphate Pyrophosphatase, ITPase, Inosine Triphosphat

ITPA, aa1-194, Recombinant, Human (Inosine Triphosphate Pyrophosphatase, ITPase, Inosine Triphosphat
Item number Size Datasheet Manual SDS Delivery time Quantity Price
I9211-10.100 100 µg - -

3 - 19 business days*

568.00€
I9211-10.500 500 µg - -

3 - 19 business days*

1,099.00€
 
ITPA, also known as Inosine triphosphate pyrophosphatase, is an enzyme that catalyzes the... more
Product information "ITPA, aa1-194, Recombinant, Human (Inosine Triphosphate Pyrophosphatase, ITPase, Inosine Triphosphat"
ITPA, also known as Inosine triphosphate pyrophosphatase, is an enzyme that catalyzes the pyrophosphohydrolysis of both ITP (inosine triphosphate) and dITP (deoxyinosine triphosphate) to IMP (inosine monophosphate) and diphosphate. IMP can be used as a substrate for purine nucleotide pathways. IMP can be phosphorylated to ITP, and ITPA can regulate the concentration of ITP in the cell by converting ITP back to IMP. Defects in ITPA result in ITPA deficiency which is thought to be inherited and is characterized by an over-accumulation of ITP in erythocytes, leukocytes and fibroblasts. Source: Recombinant corresponding to aa10194 of human ITPA protein, fused to His-tag at N-terminus, expressed in E.coli. AA Sequence: MGSSHHHHHH SSGLVPRGSH MMAASLVGKK IVFVTGNAKK LEEVVQILGD KFPCTLVAQK IDLPEYQGEP DEISIQKCQE AVRQVQGPVL VEDTCLCFNA LGGLPGPYIK WFLEKLKPEG LHQLLAGFED KSAYALCTFA LSTGDPSQPV RLFRGRTSGR IVAPRGCQDF GWDPCFQPDG YEQTYAEMPK AEKNAVSHRF RALLELQEYF GSLAA, Molecular Weight: 23.7kD (215aa) confirmed by MALDI-TOF , Enzyme Activity:, Not determined. This product is recommended for use in applications that do not require a catalytically active form of the protein. Storage and Stability: May be stored at 4°C for short-term only. Aliquot to avoid repeated freezing and thawing. Store at -20°C. Aliquots are stable for at least 6 months at -20°C. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap. Further dilutions can be made in assay buffer.
Keywords: ITPA, My049, ITPase, NTPase, C20orf37, EC=3.6.1.19, Inosine triphosphatase, Inosine triphosphate pyrophosphatase, Putative oncogene protein hlc14-06-p, Nucleoside-triphosphate diphosphatase, Non-standard purine NTP pyrophosphatase
Supplier: United States Biological
Supplier-Nr: I9211-10

Properties

Conjugate: No
Species reactivity: human
Format: Highly Purified

Handling & Safety

Storage: -20°C
Shipping: +4°C (International: +4°C)
Caution
Our products are for laboratory research use only: Not for administration to humans!
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