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Item number | Size | Datasheet | Manual | SDS | Delivery time | Quantity | Price |
---|---|---|---|---|---|---|---|
I8600-17H.10 | 10 µg | - | - |
3 - 19 business days* |
955.00€
|
If you have any questions, please use our Contact Form.
You can also order by e-mail: info@biomol.com
Larger quantity required? Request bulk
You can also order by e-mail: info@biomol.com
Larger quantity required? Request bulk
(IRAKs) are important mediators in the signal transduction of the Toll/IL-1 receptor (TIR)... more
Product information "IRAK4, Recombinant, Human (IRAK4, REN64, NY-REN-64, Interleukin-1 receptor-associated kinase 4, IRAK"
(IRAKs) are important mediators in the signal transduction of the Toll/IL-1 receptor (TIR) family. Members of the TIL family play a role in innate immune responses by coordinating host defense mechanisms. IRAK4 is the most recently discovered IRAK protein. IRAK-4 has been shown to interact with IRAK-1 and TRAF6 in an IL-1-dependent manner, and overexpression of IRAK-4 has been shown to activate NFkB as well as mitogen-activated protein (MAP) kinase pathways. Studies demonstrate that mice lacking IRAK4 are severely impaired in their IL-1, Toll-like receptor (TLR) signaling and response to viral and bacterial challenges, this indicates that IRAK4 has an important role in innate immunity. Humans lacking IRAK 4 exhibit pyogenic bacterial infections, while their blood and fibroblast cells fail to activate NF-kB. IRAK-4 is believed to be required for the LPS-induced activation of antigenpresenting cells. Source: Recombinant human IRAK4, aa2-end, with N-terminal GST tag, expressed in a Baculovirus infected Sf9 cell expression system. Molecular Weight: 77.5kD , Specific Activity: , 18pmol/min/ug, Reaction Buffer: 50mM HEPES (pH7.5), 10mM MgCl2, 1mM EGTA, 200uM ATP, 0.01% Brij-35 and 2uM substrate. Substrate: Invitrogen Z-Lyte SER/THR 7, Applications: Useful for the study of enzyme kinetics, screening inhibitors, and selectivity profiling. Other applications not tested. Recommended Dilution: The enzyme reaction was carried out for 1h at room temperature in reaction buffer. Optimal dilutions to be determined by the researcher. Storage and Stability: Aliquot to avoid repeated freezing and thawing and store at -70°C. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap. Aliquots are stable for at least 6 months.
Keywords: | EC=2.7.11.1, Renal carcinoma antigen NY-REN-64 |
Supplier: | United States Biological |
Supplier-Nr: | I8600-17H |
Properties
Conjugate: | No |
MW: | 77.5 kD |
Purity: | 95% |
Format: | Purified |
Database Information
KEGG ID : | K04733 | Matching products |
UniProt ID : | Q9NWZ3 | Matching products |
Gene ID | GeneID 51135 | Matching products |
Handling & Safety
Storage: | -80°C |
Shipping: | -20°C (International: -20°C) |
Caution
Our products are for laboratory research use only: Not for administration to humans!
Our products are for laboratory research use only: Not for administration to humans!
Information about the product reference will follow.
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