INK128

INK128
Item number Size Datasheet Manual SDS Delivery time Quantity Price
Cay11811-1 1 mg -

6 - 10 business days*

42.00€
Cay11811-5 5 mg -

6 - 10 business days*

82.00€
Cay11811-10 10 mg -

6 - 10 business days*

141.00€
Cay11811-50 50 mg -

6 - 10 business days*

295.00€
 
INK128 is an inhibitor of TORC1/2, acting as an ATP-dependent inhibitor of mTOR kinase (IC50 = 1... more
Product information "INK128"
INK128 is an inhibitor of TORC1/2, acting as an ATP-dependent inhibitor of mTOR kinase (IC50 = 1 nM). It blocks the phosphorylation of downstream substrates of both TORC1 and TORC2. INK128 interferes with the growth of cell lines which are resistant to rapamycin and pan-PI3K inhibitors. Moreover, daily, oral administration of INK128 inhibits angiogenesis and tumor growth in several xenograft models. The effects of INK128 on gene expression also reduce invasion and metastasis.Formal Name: 3-(2-amino-5-benzoxazolyl)-1-(1-methylethyl)-1H-pyrazolo[3,4-d]pyrimidin-4-amine. CAS Number: 1224844-38-5. Synonyms: MLN0128. Molecular Formula: C15H15N7O. Formula Weight: 309.3. Purity: >98%. Formulation: (Request formulation change), A crystalline solid. Solubility: DMF: 1 mg/ml, DMSO: 2 mg/ml, DMSO:PBS (pH 7.2) (1:1): 0.5 mg/ml. lambdamax: 205, 243, 292 nm. SMILES: CC(C)N1C2=NC=NC(N)=C2C(C3=CC(N=C(N)O4)=C4C=C3)=N1. InChi Code: InChI=1S/C15H15N7O/c1-7(2)22-14-11(13(16)18-6-19-14)12(21-22)8-3-4-10-9(5-8)20-15(17)23-10/h3-7H,1-2H3,(H2,17,20)(H2,16,18,19). InChi Key: GYLDXIAOMVERTK-UHFFFAOYSA-N.
Keywords: MLN0128, 3-(2-amino-5-benzoxazolyl)-1-(1-methylethyl)-1H-pyrazolo[3,4-d]pyrimidin-4-amine
Supplier: Cayman Chemical
Supplier-Nr: 11811

Properties

Application: TORC1/2 inhibitor
MW: 309.3 D
Formula: C15H15N7O
Purity: >98%
Format: Crystalline Solid

Database Information

CAS : 1224844-38-5| Matching products
KEGG ID : K07203 | Matching products

Handling & Safety

Storage: -20°C
Shipping: +20°C (International: -20°C)
Caution
Our products are for laboratory research use only: Not for administration to humans!
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