IL-23 (mouse):Fc (human) (rec.)

IL-23 (mouse):Fc (human) (rec.)
Item number Size Datasheet Manual SDS Delivery time Quantity Price
CHI-MF-11123-C050 50 µg - -

3 - 9 business days*

418.00€
 
The mouse IL-23 complex composed of the p40 subunit (aa 23-335) and the p19 subunit (aa 20-196)... more
Product information "IL-23 (mouse):Fc (human) (rec.)"
The mouse IL-23 complex composed of the p40 subunit (aa 23-335) and the p19 subunit (aa 20-196) is fused through a polypeptide linker to the Fc portion of human IgG1. Lyophilized from 0.2µm-filtered solution in PBS. 0 Interleukin-23 (IL-23) is a heterodimeric cytokine composed of two disulfide-linked subunits, a p19 subunit that is unique to IL-23, and a p40 subunit that is shared with IL-12 (1-5). Although p19 is expressed by activated macrophages, dendritic cells, T cells, and endothelial cells, only activated macrophages and dendritic cells express p40 concurrently to produce IL-23. The functional IL-23 receptor complex consists of two receptor subunits, the IL-12 receptor beta 1 subunit (IL-12 R&beta:1) and the IL-23-specific receptor subunit (IL-23 R). IL-23 has biological activities that are similar to, but distinct from IL-12. Both IL-12 and IL-23 induce proliferation and IFN-gamma production by human T cells. While IL-12 acts on both naie and memory human T cells, the effects of IL-23 is restricted to memory T cells. In mouse, IL-23 but not IL-12, has also been shown to induce memory T cells to secret IL-17, a potent proinflammatory cytokine. IL-12 and IL-23 can induce IL-12 production from mouse splenic DC of both the CD8-and CD8 subtypes, however only IL-23 can act directly on CD8 DC to mediate immunogenic presentation of poorly immunogenic tumor/self peptide.
Keywords: Interleukin-23, Il12b, IL-12B, CLMF p40, IL-12 subunit p40, Interleukin-12 subunit beta, Cytotoxic lymphocyte maturation factor 40 kDa subunit, Il23a, IL-23-A, IL-23p19, IL-23 subunit alpha, Interleukin-23 subunit p19, Interleukin-23 subunit alpha
Supplier: Chimerigen Laboratories
Supplier-Nr: MF-11123

Properties

Application: Bioassays
Conjugate: No
Host: Hamster cells
Species reactivity: mouse
Purity: >98%
Format: Lyophilized

Handling & Safety

Storage: -20°C
Shipping: +4°C (International: +4°C)
Caution
Our products are for laboratory research use only: Not for administration to humans!
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