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Item number | Size | Datasheet | Manual | SDS | Delivery time | Quantity | Price |
---|---|---|---|---|---|---|---|
CHI-MF-12021R-C025 | 25 µg | - | - |
3 - 9 business days* |
209.00€
|
Interleukin-21 receptor (IL-21R) is a type I transmembrane glycoprotein within the class I... more
Product information "IL-21R (mouse):Fc (mouse) (rec.) (nonlytic)"
Interleukin-21 receptor (IL-21R) is a type I transmembrane glycoprotein within the class I cytokine receptor family, type 4 subfamily. Complex formation between IL-21R and the common gamma chain (gamma-c) is required for signaling. IL-21R is expressed mainly on B cells (highest on mature, activated, follicular and germinal center B cells), NK cells and activated T cells, but is also found on dendritic cells, alternatively activated macrophages, intestinal lamina propria fibroblasts and epithelial cells and keratinocytes. B cell IL-21R engagement induces Blimp1 (which mediates plasma cell differentiation) and is important for memory responses. IL-21R engagement on mouse NK cells enhances their cytotoxic activity and IFN-gamma production. IL-21R engagement on CD8 T cells aids control of viral infection and tumor growth, IL-21R is also necessary for sufficient numbers of regulatory T cells to combat chronic inflammation. IL-21R expression is often upregulated in allergic skin inflammation, systemic lupus erythematosus and diffuse large B cell lymphoma (DLBCL).
Keywords: | Interleukin-21 Receptor, CD360, NILR |
Supplier: | Chimerigen Laboratories |
Supplier-Nr: | MF-12021R |
Properties
Application: | Bioassays |
Conjugate: | No |
Host: | Hamster cells |
Species reactivity: | mouse |
Purity: | >98% |
Format: | Lyophilized |
Database Information
KEGG ID : | K05075 | Matching products |
UniProt ID : | Q9JHX3 | Matching products |
Gene ID | GeneID 60504 | Matching products |
Handling & Safety
Storage: | -20°C |
Shipping: | +4°C (International: +4°C) |
Caution
Our products are for laboratory research use only: Not for administration to humans!
Our products are for laboratory research use only: Not for administration to humans!
Information about the product reference will follow.
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