IL-21R (mouse):Fc (mouse) (rec.) (nonlytic)

IL-21R (mouse):Fc (mouse) (rec.) (nonlytic)
Item number Size Datasheet Manual SDS Delivery time Quantity Price
CHI-MF-12021R-C025 25 µg - -

3 - 9 business days*

209.00€
 
Interleukin-21 receptor (IL-21R) is a type I transmembrane glycoprotein within the class I... more
Product information "IL-21R (mouse):Fc (mouse) (rec.) (nonlytic)"
Interleukin-21 receptor (IL-21R) is a type I transmembrane glycoprotein within the class I cytokine receptor family, type 4 subfamily. Complex formation between IL-21R and the common gamma chain (gamma-c) is required for signaling. IL-21R is expressed mainly on B cells (highest on mature, activated, follicular and germinal center B cells), NK cells and activated T cells, but is also found on dendritic cells, alternatively activated macrophages, intestinal lamina propria fibroblasts and epithelial cells and keratinocytes. B cell IL-21R engagement induces Blimp1 (which mediates plasma cell differentiation) and is important for memory responses. IL-21R engagement on mouse NK cells enhances their cytotoxic activity and IFN-gamma production. IL-21R engagement on CD8 T cells aids control of viral infection and tumor growth, IL-21R is also necessary for sufficient numbers of regulatory T cells to combat chronic inflammation. IL-21R expression is often upregulated in allergic skin inflammation, systemic lupus erythematosus and diffuse large B cell lymphoma (DLBCL).
Keywords: Interleukin-21 Receptor, CD360, NILR
Supplier: Chimerigen Laboratories
Supplier-Nr: MF-12021R

Properties

Application: Bioassays
Conjugate: No
Host: Hamster cells
Species reactivity: mouse
Purity: >98%
Format: Lyophilized

Handling & Safety

Storage: -20°C
Shipping: +4°C (International: +4°C)
Caution
Our products are for laboratory research use only: Not for administration to humans!
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