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IL-10 (human): Fc (human) (rec.)

ART NR.: CHI-HF-21010-C010 (10 µg)
CHI-HF-21010-C050 (50 µg)

Hersteller: Chimerigen

Datenblatt

Anwendungen: Bioassays

Exprimiert in: Hamster cells

Ursprungs-Art: human

Reinheit: >98%

Format: lyophilized

UniProt ID: P22301
Suche mit UniProt ID

Geninformationen: GeneID 3586

Schlagworte: IL10, CSIF, IL-10, Interleukin-10, Cytokine synthesis inhibitory factor

CHI-HF-21010-C010

10 µg

220 €

CHI-HF-21010-C050

50 µg

385 €

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Bemerkungen: Unfortunately, most cytokines have short circulating half-lives. With the creation of a group of new immunoglobulin- based cytokine fusion proteins, in which a cytokine sequence had been genetically fused to the hinge, CH2 and CH3 regions of an immunoglobulin, these cytokine fusion proteins possess both the biological functions of the cytokine moiety and the prolonged circulating half-life determined by the Fc domain. Interleukin-10 (IL-10) is a cytokine produced by activated Th2 cells, B cells, keratinocytes and monocytes/macrophages. In vitro murine and human IL-10 inhibits cytokine synthesis by Th1 cells, natural killer cells, and monocytes/macrophages. Several studies have suggested the potential application of IL-10 as an anti-inflammatory agent in the treatment of septic shock and as an immunosuppressive agent in certain T-cell mediated autoimmune diseases.

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