IL-1 Receptor Type I (human):Fc (human, rec.)

(3 x 50µg). Human IL-1RI (interleukin-1 receptor type I) (amino acids 21-336) is fused at the C-terminus to the Fc portion of human IgG1. Blocks IL-1 beta activity. Lyophilized. Contains PBS. IL-1RI is the receptor for interleukin-1 alpha (IL-1A), beta (IL-1B), and interleukin-1 receptor antagonist protein (IL-1RA). Binding to the agonist leads to the activation of NF-kappaB. Signaling involves formation of a ternary complex containing IL1RAP, leading the activation of TOLLIP, MYD88, and IRAK1 or IRAK2.