I-BET762

I-BET762
Item number Size Datasheet Manual SDS Delivery time Quantity Price
Cay10676-1 1 mg -

6 - 10 business days*

43.00€
Cay10676-5 5 mg -

6 - 10 business days*

146.00€
Cay10676-10 10 mg -

6 - 10 business days*

267.00€
Cay10676-25 25 mg -

6 - 10 business days*

611.00€
 
The bromodomain and extra terminal domain (BET) family of proteins, including BRD2, BRD3, and... more
Product information "I-BET762"
The bromodomain and extra terminal domain (BET) family of proteins, including BRD2, BRD3, and BRD4, affect inflammatory gene expression by controlling the assembly of histone acetylation-dependent chromatin complexes. I-BET762 is a synthetic compound which interacts with BET proteins with high-affinity (Kd = 32.5-42.5 nM). It blocks binding of BET proteins with acetylated histones, disrupting the formation of chromatin complexes involved in the expression of specific inflammatory genes in activated macrophages. Through these actions, I-BET762 provides protection against bacteria-induced sepsis and lipopolysaccharide-triggered endotoxic shock.Formal Name: (S)-2-(6-(4-chlorophenyl)-8-methoxy-4H-benzo[f][1,2,4]triazolo[4,3-a][1,4]diazepin-4-yl)-N-ethylacetamide. CAS Number: 1260907-17-2. Synonyms: GSK525762A. Molecular Formula: C22H22ClN5O2. Formula Weight: 423.9. Purity: >98%. Formulation: (Request formulation change), A crystalline solid. Solubility: DMF: 30 mg/ml, DMSO: 20 mg/ml, Ethanol: 30 mg/ml, Ethanol:PBS (pH 7.2) (1:1): 0.5 mg/ml. SMILES: COC1=CC(C(C2=CC=C(Cl)C=C2)=N[C@H]3CC(N(CC)[H])=O)=C(N4C3=NN=C4C)C=C1. InChi Code: InChI=1S/C22H22ClN5O2/c1-4-24-20(29)12-18-22-27-26-13(2)28(22)19-10-9-16(30-3)11-17(19)21(25-18)14-5-7-15(23)8-6-14/h5-11,18H,4,12H2,1-3H3,(H,24,29)/t18-/m0/s1. InChi Key: AAAQFGUYHFJNHI-SFHVURJKSA-N.
Keywords: GSK525762A, (S)-2-(6-(4-chlorophenyl)-8-methoxy-4H-benzo[f][1,2,4]triazolo[4,3-a][1,4]diazepin-4-yl)-N-ethylacetamide
Supplier: Cayman Chemical
Supplier-Nr: 10676

Properties

Application: BET protein studies
MW: 423.9 D
Formula: C22H22ClN5O2
Purity: >98%
Format: Crystalline Solid

Database Information

CAS : 1260907-17-2| Matching products

Handling & Safety

Storage: -20°C
Shipping: +20°C (International: -20°C)
Signal Word: Danger
GHS Hazard Pictograms:
H Phrases: H301, H314, H318, H360, H373
P Phrases: P201, P202, P260, P264, P270, P280, P314, P321, P363, P301+P310, P301+P330+P331, P303+P361+P353, P304+P340, P305+P351+P338, P308+P313, P405, P501
Caution
Our products are for laboratory research use only: Not for administration to humans!
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