- Search results for Cay11715
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11 products were found matching "Cay11715"!
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Item number: Cay11715-25
Hypophyllanthin is an active principle of P. amarus, a plant studied for its potential to treat hepatotoxicity. In Caco-2 cells 100 µM hypophyllanthin has been shown to reversibly inhibit P-glycoprotein (also known as multidrug resistance protein 1 (MDR1)) function without effect on MDR2 activity.Formal Name:...
Keywords: | NSC 619044, (7S,8S,9R)-9-(3,4-dimethoxyphenyl)-6,7,8,9-tetrahydro-4-methoxy-7,8-bis(methoxymethyl)-naphtho[1,2-d]-1,3-dioxole |
Application: | MDR1 inhibitor |
CAS | 33676-00-5 |
MW: | 430.5 D |
From 84.00€
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Item number: Cay11711-5
alpha-Ecdysone is a prohormone of 20-hydroxy ecdysone (Cay-16145), an insect-molting, ecdysteroid hormone. The insect neurohormone, prothoracicotropic hormone, stimulates prothoracic glands to release alpha-ecdysone, which is then rapidly converted to its active metabolite, 20-hydroxy ecdysone.Formal Name:...
Keywords: | (5beta)-2beta,3beta,14,22R,25-pentahydroxy-cholest-7-en-6-one |
Application: | Prohormone |
CAS | 3604-87-3 |
MW: | 464.6 D |
From 72.00€
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Item number: Cay17111-5
Branched fatty acid esters of hydroxy fatty acids (FAHFAs) are newly identified endogenous lipids regulated by fasting and high-fat feeding and associated with insulin sensitivity in mice. 13-POHSA is a FAHFA consisting of palmitoleic acid esterified to 13-hydroxy stearic acid. The levels of POHSA are significantly...
Keywords: | (Z)-13-(hexadec-9-enoyloxy)octadecanoic acid |
Application: | Endogenous lipid |
CAS | 2126038-97-7 |
MW: | 536.9 D |
From 84.00€
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Item number: Cay17715-5
GSK2193874 is a potent antagonist of TRPV4 channels, blocking the influx of calcium induced by the TRPV4 agonist GSK634775 with IC50 values of 2, 5, and 40 nM for rat, mouse, and human isoforms, respectively. It is selective for TRPV4 over ~200 other human receptors, channels, and enzymes. GSK2193874 is effective in...
Keywords: | 3-([1,4'-bipiperidin]-1'-ylmethyl)-7-bromo-N-(1-phenylcyclopropyl)-2-[3-(trifluoromethyl)phenyl]-4-quinolinecarboxamide |
Application: | TRPV4 antagonist |
CAS | 1336960-13-4 |
MW: | 691.6 D |
From 43.00€
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Item number: Cay17115-1
Branched fatty acid esters of hydroxy fatty acids (FAHFAs) are newly identified endogenous lipids regulated by fasting and high-fat feeding and associated with insulin sensitivity in mice. Structurally these esters are comprised of a C-16 or C-18 fatty acid (e.g., palmitoleic, palmitic, oleic, or stearic acid)...
Keywords: | 5-(oleoyloxy)octadecanoic acid |
Application: | Branched fatty acid ester of hydroxy fatty acids (FAHFA) |
CAS | 1997286-66-4 |
MW: | 564.9 D |
From 84.00€
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Item number: Cay17155-5
Milbemycin A4 is the prominent member of a complex family of macrocyclic lactones that contain a characteristic spiroketal group produced from the fermentation of soil bacterium S. hygroscopicus subsp. aureolacrimosus. As a compound that potentiates glutamate and GABA-gated chloride-channel opening, milbemycin 4 is...
Keywords: | Antibiotic B 41A4, Milbemycin alpha3, (6R,25R)-5-O-demethyl-28-deoxy-6,28-epoxy-25-ethyl-milbemycin B |
Application: | Glutamate & GABA-gated chloride-channel opener, Nematocide, Insecticide |
CAS | 51596-11-3 |
MW: | 542.7 D |
From 570.00€
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Item number: Cay11713-5
Gymnemagenin is the aglycone core of gymnemic acids A and B, triterpenoid sweetness inhibitors derived from G. sylvestre. It is used as a biomarker for the quantification of gymnemic acids in medicinal plant extracts.Formal Name: 4alpha-olean-12-ene-3beta,16beta,21beta,22alpha,23,28-hexol. CAS Number: 22467-07-8....
Keywords: | 4alpha-olean-12-ene-3beta,16beta,21beta,22alpha,23,28-hexol |
Application: | Biomarker |
CAS | 22467-07-8 |
MW: | 506.7 D |
From 80.00€
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Item number: Cay11712-5
beta-Elemonic acid is a triterpene isolated from Boswellia (Burseraceae) that exhibits anticancer activity. It inhibits growth of non-small cell lung cancer (NSCLC) A549 cells (IC50 = 6.92 µM) in vitro. beta-Elemonic acid induces apoptosis and cytotoxicity in A549 cells in a dose-dependent manner but has no effect...
Keywords: | 3-oxo Tirucallic Acid, 3-Oxotirucallenoic Acid, Elemadienonic Acid,... |
Application: | Anticancer compound |
CAS | 28282-25-9 |
MW: | 454.7 D |
From 125.00€
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Item number: Cay11714-5
Hexahydrocurcumin is a natural product and an active metabolite of curcumin. It reduces prostaglandin E2 (PGE2) production stimulated by phorbol 12-myristate 13-acetate (PMA, Cay-10008014) by 37% in human colonic epithelial cells when used at a concentration of 20 µM. Hexahydrocurcumin (3.125-25 µM) inhibits...
Keywords: | 5-hydroxy-1,7-bis(4-hydroxy-3-methoxyphenyl)-3-heptanone |
Application: | COX-2 inhibitor |
CAS | 36062-05-2 |
MW: | 374.4 D |
From 115.00€
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Item number: Cay11717-25
Lysergol is an ergot alkaloid that has been found in S. sorghi and an agonist of the serotonin (5-HT) receptor subtypes 5-HT1A, 5-HT2A, and 5-HT2C (EC50s = 73, 1.6, and 6.6 nM, respectively, in a FLIPR assay). It induces contractions in isolated rat tail arteries (EC50 = 436.5 nM). Lysergol (10 µg/ml) also enhances...
Keywords: | (+)-Lysergol, NSC 196867, 9,10-didehydro-6-methyl-ergoline-8beta-methanol |
Application: | Ergot alkaloid, 5-HT1A/5-HT2A/5-HT2C receptor agonist |
CAS | 602-85-7 |
MW: | 254.3 D |
From 122.00€
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Item number: Cay11710-25
Diacerein is a prodrug form of the anthraquinone derivative rhein (Cay-17345). It inhibits RANKL- and IL-1beta-induced differentiation of RAW 264.7 cells into osteoclasts when used at a concentration of 20 µg/ml. Diacerein (20 µg/ml) reduces levels of interleukin-1beta-converting enzyme (ICE), also known as...
Keywords: | 4,5-Diacetylrhein, DAR, SF 277, 4,5-bis(acetyloxy)-9,10-dihydro-9,10-dioxo-2-anthracenecarboxylic acid |
Application: | Antiinflammatory, IL-1beta receptor expression down-regulator |
CAS | 13739-02-1 |
MW: | 368.3 D |
From 60.00€
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