12 products were found matching "Cay10342-50"!

The aryl hydrocarbon receptor (AhR) is a ligand-dependent intracellular transcription factor whose ligands include some of the most infamous xenobiotics, including dioxin, benzo[a]pyrene, and numerous polyaromatics from soot and coal tar. PDM 2 is an analog of resveratrol acting as a potent and selective aryl...

5-OxoETE is a polyunsaturated keto acid formed by the oxidation of 5-HETE in human neutrophils by a specific dehydrogenase. It stimulates cytosolic calcium levels in neutrophils with an EC50 value of 2 nM. 5-OxoETE selectively stimulates the migration and degranulation of eosinophils and activates the MAPK pathway...

Bicalutamide is a non-steroidal androgen receptor antagonist that binds the androgen receptor (Ki = 12.5 µM, IC50 = 1.2 µM), preventing its activation and subsequent upregulation of androgen responsive genes by androgenic hormones. Bicalutamide is frequently used to examine the role of androgen receptor inactivation...

Formaldehyde dehydrogenase (FDH) is a zinc-containing metalloenzyme that catalyzes the oxidation of formaldehyde to formate. P. putida FDH is an NAD-dependent enzyme that is a member of the class III alcohol dehydrogenase family.Synonyms: FDH. Purity: >90% estimated by SDS-PAGE. Source: Active recombinant N-terminal...

Protein Arginine Methyltransferases (PRMTs) are S-adenosyl-L-methionine-dependent enzymes that catalyze post-translational modification of arginine residues by methylation in three different ways: monomethylation, symmetric dimethylation, or asymmetric dimethylation at terminal arginine guanidino nitrogen atoms....

5-Bromotetralone is a synthetic intermediate useful for pharmaceutical synthesis.Formal Name: 5-bromo-3,4-dihydro-1(2H)-naphthalenone. CAS Number: 68449-30-9. Molecular Formula: C10H9BrO. Formula Weight: 225.1. Purity: >98%. Formulation: (Request formulation change), A crystalline solid. Solubility: DMF: 10 mg/ml,...

8-iso Prostaglandin E2 (8-iso PGE2) is one of several isoprostanes produced from arachidonic acid during lipid peroxidation. It is a potent renal vasoconstrictor in the rat. 8-iso PGE2 inhibits U-46619 or I-BOP-induced platelet aggregation with IC50 values of 0.5 and 5 µM, respectively. When infused into the renal...

8-iso Prostaglandin E2 isopropyl ester (8-iso PGE2 isopropyl ester) is a more lipophilic form of the free acid, 8-iso PGE2. Prostaglandin esters have enhanced lipid solubility compared to their parent compounds. They are generally hydrolyzed to the free acid upon in vivo administration, making the esters useful...

Triclosan is an antibiotic and antifungal. It is an inhibitor of E. coli enoyl-acyl carrier protein reductase (FabI) and FabI containing a glycine-to-valine substitution at position 93 (FabIG93V, IC50s = 2 and 10 µM, respectively). Triclosan is active against the bacteria M. epidermidis, M. lysodeikticus, S. aureus,...

(±)5-HETE is one of the six monohydroxy fatty acids produced by the non-enzymatic oxidation of arachidonic acid. It contains equal amounts of 5(S)-HETE and 5(R)-HETE. (±)5-HETE induces the aggregation of isolated neutrophils with an IC50 value of 200 nM.Formal Name: (±)5-hydroxy-6E,8Z,11Z,14Z-eicosatetraenoic acid....

Mofezolac is an inhibitor of COX-1 (IC50 = 14 nM). It is selective for COX-1 over COX-2 (IC50 = 440 nM). Mofezolac (1 µg/ml) protects against LPS-induced cell death in BV-2 microglia. In vivo, mofezolac (6 mg/kg, i.p.) reduces hippocampal microglial activation and prostaglandin E2 (PGE2, Cay-14010) production in a...

Palmitoyl ethanolamide (PEA) is an endogenous cannabinoid found in brain, liver, and other mammalian tissues. PEA has also been isolated from egg yolk, and found to have antianaphylactic and anti-inflammatory activity in vitro. Heptadecanoyl ethanolamide is a synthetic analog of PEA which incorporates an...