- Search results for Cay10342-25
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13 products were found matching "Cay10342-25"!
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Item number: Cay34225-100
5(R)-HETE is a rare lipoxygenase product of arachidonic acid. Nearly all plant and animal 5-LOs produce 5(S)-HETE, but the presence of a 5(R)-LO and the synthesis of 5(R)-HpETE and 5(R)-HETE have been confirmed in oocytes of the bivalve mollusk, S. solidissima. 5(R)-HETE is more potent than the (S)-enantiomer as a...
Keywords: | 5R-hydroxy-6E,8Z,11Z,14Z-eicosatetraenoic acid |
Application: | Bioactive lipid assays |
CAS | 61641-47-2 |
MW: | 320.5 D |
From 181.00€
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Item number: Cay10325-1
Chemokine-Like Receptor 1 (CMKLR1) is a G protein-coupled receptor relevant to the cellular chemotaxis of dendritic cells and macrophages. This receptor is also expressed in brain, liver, lung, and kidney tissues. Chemerin, or TIG2, has been identified as the natural ligand for this receptor. Resolvin E1 has also...
Keywords: | Anti-CMKLR1, Anti-CHEMR23, Anti-Chemokine-like receptor 1, Anti-Chemokine-like receptor 1, Anti-G-protein coupled receptor... |
Application: | FC, IF, IHC, WB |
Host: | Rabbit |
Species reactivity: | human |
422.00€
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Item number: Cay14325-25
2-deoxy-D-Glucose is a glucose antimetabolite and an inhibitor of glycolysis. It inhibits hexokinase, the enzyme that converts glucose to glucose-6-phosphate, as well as phosphoglucose isomerase, the enzyme that converts glucose-6-phosphate to fructose-6-phosphate. 2-deoxy-D-glucose (16 mM) induces apoptosis in...
Keywords: | Ba 2758, NSC 15193, 2-deoxy-D-arabino-hexose |
Application: | Non-metabolizable glucose analog |
CAS | 154-17-6 |
MW: | 164.2 D |
From 68.00€
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Item number: Cay10345-1
GPR17 is a G protein-coupled receptor that has been identified as a dualistic receptor recognizing signals from two unrelated chemical families: nucleotides and cysteinyl leukotrienes (CysLTs). The deorphanization of GPR17 supports the suggested crosstalk between nucleotides and CysLTs during inflammation and...
Keywords: | G Protein-Coupled Receptor 17 |
Application: | FC, ICC, WB |
177.00€
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Item number: Cay10341-25
12-Lipoxygenase (12-LO) catalyzes the formation of 12-HpETE from arachidonic acid. There are two main types of 12-LO, platelet-type and leukocyte-type, which share only 60% identity at the amino acid level and strongly differ in substrate specificity and enzyme kinetics. Leukocyte-type 12-LO has the ability to also...
Keywords: | Alox12, P-12LO, P-12LO, Alox12p, 12S-LOX, 12S-LOX, 12S-lipoxygenase, 12S-lipoxygenase, Lipoxin synthase 12-LO, Lipoxin... |
Application: | Enzyme activity |
MW: | 76,4 kD |
489.00€
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Item number: Cay10348-25
Sphingosine kinase (SPHK) is an important enzyme in the sphingolipid metabolic pathway. SPHKs phosphorylate D-erythro-sphingosine to yield sphingosine-1-phosphate (S1P). To date two isoforms of SPHK, SPHK1 and SPHK2, have been identified & characterized from mammalian cells. Among them, SPHK1 has been implicated to...
Keywords: | SK 1, SK 1, SPK 1, SPK 1, Sphingosine kinase 1, Sphingosine kinase 1, Acetyltransferase SPHK1, Acetyltransferase SPHK1 |
Application: | Enzyme activity |
MW: | 47,5 kD |
571.00€
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Item number: Cay34210-25
(±)5-HETE is one of the six monohydroxy fatty acids produced by the non-enzymatic oxidation of arachidonic acid. It contains equal amounts of 5(S)-HETE and 5(R)-HETE. (±)5-HETE induces the aggregation of isolated neutrophils with an IC50 value of 200 nM.Formal Name: (±)5-hydroxy-6E,8Z,11Z,14Z-eicosatetraenoic acid....
Keywords: | (±)5-hydroxy-6E,8Z,11Z,14Z-eicosatetraenoic acid |
Application: | Bioactive lipid studies |
CAS | 73307-52-5 |
MW: | 320.5 D |
From 97.00€
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Item number: Cay21034-25
DprE1-IN-2 is an antitubercular agent that is active against M. tuberculosis in vitro, with MIC values ranging from 0.5 to 1.56 µM. It is an inhibitor of decaprenylphosphoryl-beta-D-ribose 2'-epimerase (DprE1, IC50 = 32 nM), an enzyme involved in mycobacterial cell wall biogenesis. DrpE1-IN-2 (300 mg/kg) reduces...
Keywords: | 1-[[6-(dimethylamino)-5-methyl-4-pyrimidinyl]methyl]-N-(2-hydroxyethyl)-6-methyl-1H-pyrrolo[3,2-b]pyridine-3-carboxamide |
Application: | DprE1 inhibitor |
CAS | 1615713-87-5 |
MW: | 368.4 D |
From 50.00€
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Item number: Cay34102-25
Mofezolac is an inhibitor of COX-1 (IC50 = 14 nM). It is selective for COX-1 over COX-2 (IC50 = 440 nM). Mofezolac (1 µg/ml) protects against LPS-induced cell death in BV-2 microglia. In vivo, mofezolac (6 mg/kg, i.p.) reduces hippocampal microglial activation and prostaglandin E2 (PGE2, Cay-14010) production in a...
Keywords: | N-22, 3,4-bis(4-methoxyphenyl)-5-isoxazoleacetic acid |
Application: | COX-1 inhibitor |
CAS | 78967-07-4 |
MW: | 339.3 D |
From 60.00€
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Item number: Cay10225-1
To be used in conjunction with Cayman's GPR55 Polyclonal Antibody (Cay-10224) to block protein-antibody complex formation during immunochemical analysis of GPR55 for Western blot (WB).Synonyms: G Protein-Coupled Receptor 55, LIP1, Lysophosphatidylinositol Receptor 1. Formulation: (Request formulation change), 200 µg...
Keywords: | G Protein-Coupled Receptor 55, LIP1, Lysophosphatidylinositol Receptor 1 |
Application: | ICC, IF, IHC, WB |
177.00€
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Item number: Cay10643-25
JWH 182 is a potent synthetic cannabinoid (CB), activating the central CB1 receptor with a Ki value of 0.65 nM and the peripheral CB2 receptor with a Ki value of 1.1 nM. Its effects in cells and animals are unknown.Formal Name: (1-pentyl-1H-indol-3-yl)(4-propyl-1-naphthalenyl)-methanone. CAS Number: 824960-02-3....
Keywords: | (1-pentyl-1H-indol-3-yl)(4-propyl-1-naphthalenyl)-methanone |
Application: | Analytical reference standard, Potent synthetic cannabinoid |
CAS | 824960-02-3 |
MW: | 383.5 D |
From 241.00€
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Item number: Cay10443-25
SB939 is a pan-inhibitor of histone deacetylases (HDACs, Kis = 16-247 nM for HDAC1-11). It inhibits proliferation of A2780, COLO 205, HCT116, and PC3 cancer cells (IC50s = 0.48, 0.56, 0.48, and 0.34 µM, respectively). SB939 (50 and 100 mg/kg) reduces tumor growth and increases survival in an HCT116 mouse xenograft...
Keywords: | Pracinostat, 3-[2-butyl-1-[2-(diethylamino)ethyl]-1H-benzimidazol-5-yl]-N-hydroxy-2E-propenamide |
Application: | HDAC inhibitor |
CAS | 929016-96-6 |
MW: | 358.5 D |
From 60.00€
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