13 products were found matching "Cay10342-25"!

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5(R)-HETE
5(R)-HETE

Item number: Cay34225-100

5(R)-HETE is a rare lipoxygenase product of arachidonic acid. Nearly all plant and animal 5-LOs produce 5(S)-HETE, but the presence of a 5(R)-LO and the synthesis of 5(R)-HpETE and 5(R)-HETE have been confirmed in oocytes of the bivalve mollusk, S. solidissima. 5(R)-HETE is more potent than the (S)-enantiomer as a...
Keywords: 5R-hydroxy-6E,8Z,11Z,14Z-eicosatetraenoic acid
Application: Bioactive lipid assays
CAS 61641-47-2
MW: 320.5 D
From 181.00€ *
Review
Anti-Chemokine-Like Receptor 1
Anti-Chemokine-Like Receptor 1

Item number: Cay10325-1

Chemokine-Like Receptor 1 (CMKLR1) is a G protein-coupled receptor relevant to the cellular chemotaxis of dendritic cells and macrophages. This receptor is also expressed in brain, liver, lung, and kidney tissues. Chemerin, or TIG2, has been identified as the natural ligand for this receptor. Resolvin E1 has also...
Keywords: Anti-CMKLR1, Anti-CHEMR23, Anti-Chemokine-like receptor 1, Anti-Chemokine-like receptor 1, Anti-G-protein coupled receptor...
Application: FC, IF, IHC, WB
Host: Rabbit
Species reactivity: human
422.00€ *
Review
2-deoxy-D-Glucose
2-deoxy-D-Glucose

Item number: Cay14325-25

2-deoxy-D-Glucose is a glucose antimetabolite and an inhibitor of glycolysis. It inhibits hexokinase, the enzyme that converts glucose to glucose-6-phosphate, as well as phosphoglucose isomerase, the enzyme that converts glucose-6-phosphate to fructose-6-phosphate. 2-deoxy-D-glucose (16 mM) induces apoptosis in...
Keywords: Ba 2758, NSC 15193, 2-deoxy-D-arabino-hexose
Application: Non-metabolizable glucose analog
CAS 154-17-6
MW: 164.2 D
From 68.00€ *
Review
GPR17 (C-Term) Blocking Peptide
GPR17 (C-Term) Blocking Peptide

Item number: Cay10345-1

GPR17 is a G protein-coupled receptor that has been identified as a dualistic receptor recognizing signals from two unrelated chemical families: nucleotides and cysteinyl leukotrienes (CysLTs). The deorphanization of GPR17 supports the suggested crosstalk between nucleotides and CysLTs during inflammation and...
Keywords: G Protein-Coupled Receptor 17
Application: FC, ICC, WB
177.00€ *
Review
12-Lipoxygenase (platelet-type, mouse recombinant)
12-Lipoxygenase (platelet-type, mouse recombinant)

Item number: Cay10341-25

12-Lipoxygenase (12-LO) catalyzes the formation of 12-HpETE from arachidonic acid. There are two main types of 12-LO, platelet-type and leukocyte-type, which share only 60% identity at the amino acid level and strongly differ in substrate specificity and enzyme kinetics. Leukocyte-type 12-LO has the ability to also...
Keywords: Alox12, P-12LO, P-12LO, Alox12p, 12S-LOX, 12S-LOX, 12S-lipoxygenase, 12S-lipoxygenase, Lipoxin synthase 12-LO, Lipoxin...
Application: Enzyme activity
MW: 76,4 kD
489.00€ *
Review
Sphingosine Kinase 1 (human, recombinant)
Sphingosine Kinase 1 (human, recombinant)

Item number: Cay10348-25

Sphingosine kinase (SPHK) is an important enzyme in the sphingolipid metabolic pathway. SPHKs phosphorylate D-erythro-sphingosine to yield sphingosine-1-phosphate (S1P). To date two isoforms of SPHK, SPHK1 and SPHK2, have been identified & characterized from mammalian cells. Among them, SPHK1 has been implicated to...
Keywords: SK 1, SK 1, SPK 1, SPK 1, Sphingosine kinase 1, Sphingosine kinase 1, Acetyltransferase SPHK1, Acetyltransferase SPHK1
Application: Enzyme activity
MW: 47,5 kD
571.00€ *
Review
(±)5-HETE
(±)5-HETE

Item number: Cay34210-25

(±)5-HETE is one of the six monohydroxy fatty acids produced by the non-enzymatic oxidation of arachidonic acid. It contains equal amounts of 5(S)-HETE and 5(R)-HETE. (±)5-HETE induces the aggregation of isolated neutrophils with an IC50 value of 200 nM.Formal Name: (±)5-hydroxy-6E,8Z,11Z,14Z-eicosatetraenoic acid....
Keywords: (±)5-hydroxy-6E,8Z,11Z,14Z-eicosatetraenoic acid
Application: Bioactive lipid studies
CAS 73307-52-5
MW: 320.5 D
From 97.00€ *
Review
DprE1-IN-2
DprE1-IN-2

Item number: Cay21034-25

DprE1-IN-2 is an antitubercular agent that is active against M. tuberculosis in vitro, with MIC values ranging from 0.5 to 1.56 µM. It is an inhibitor of decaprenylphosphoryl-beta-D-ribose 2'-epimerase (DprE1, IC50 = 32 nM), an enzyme involved in mycobacterial cell wall biogenesis. DrpE1-IN-2 (300 mg/kg) reduces...
Keywords: 1-[[6-(dimethylamino)-5-methyl-4-pyrimidinyl]methyl]-N-(2-hydroxyethyl)-6-methyl-1H-pyrrolo[3,2-b]pyridine-3-carboxamide
Application: DprE1 inhibitor
CAS 1615713-87-5
MW: 368.4 D
From 50.00€ *
Review
Mofezolac
Mofezolac

Item number: Cay34102-25

Mofezolac is an inhibitor of COX-1 (IC50 = 14 nM). It is selective for COX-1 over COX-2 (IC50 = 440 nM). Mofezolac (1 µg/ml) protects against LPS-induced cell death in BV-2 microglia. In vivo, mofezolac (6 mg/kg, i.p.) reduces hippocampal microglial activation and prostaglandin E2 (PGE2, Cay-14010) production in a...
Keywords: N-22, 3,4-bis(4-methoxyphenyl)-5-isoxazoleacetic acid
Application: COX-1 inhibitor
CAS 78967-07-4
MW: 339.3 D
From 60.00€ *
Review
GPR55 Blocking Peptide
GPR55 Blocking Peptide

Item number: Cay10225-1

To be used in conjunction with Cayman's GPR55 Polyclonal Antibody (Cay-10224) to block protein-antibody complex formation during immunochemical analysis of GPR55 for Western blot (WB).Synonyms: G Protein-Coupled Receptor 55, LIP1, Lysophosphatidylinositol Receptor 1. Formulation: (Request formulation change), 200 µg...
Keywords: G Protein-Coupled Receptor 55, LIP1, Lysophosphatidylinositol Receptor 1
Application: ICC, IF, IHC, WB
177.00€ *
Review
JWH 182
JWH 182

Item number: Cay10643-25

JWH 182 is a potent synthetic cannabinoid (CB), activating the central CB1 receptor with a Ki value of 0.65 nM and the peripheral CB2 receptor with a Ki value of 1.1 nM. Its effects in cells and animals are unknown.Formal Name: (1-pentyl-1H-indol-3-yl)(4-propyl-1-naphthalenyl)-methanone. CAS Number: 824960-02-3....
Keywords: (1-pentyl-1H-indol-3-yl)(4-propyl-1-naphthalenyl)-methanone
Application: Analytical reference standard, Potent synthetic cannabinoid
CAS 824960-02-3
MW: 383.5 D
From 241.00€ *
Review
SB939
SB939

Item number: Cay10443-25

SB939 is a pan-inhibitor of histone deacetylases (HDACs, Kis = 16-247 nM for HDAC1-11). It inhibits proliferation of A2780, COLO 205, HCT116, and PC3 cancer cells (IC50s = 0.48, 0.56, 0.48, and 0.34 µM, respectively). SB939 (50 and 100 mg/kg) reduces tumor growth and increases survival in an HCT116 mouse xenograft...
Keywords: Pracinostat, 3-[2-butyl-1-[2-(diethylamino)ethyl]-1H-benzimidazol-5-yl]-N-hydroxy-2E-propenamide
Application: HDAC inhibitor
CAS 929016-96-6
MW: 358.5 D
From 60.00€ *
Review
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