H-8 (hydrochloride)

H-8 (hydrochloride)
Item number Size Datasheet Manual SDS Delivery time Quantity Price
Cay10010249-5 5 mg -

6 - 10 business days*

50.00€
Cay10010249-10 10 mg -

6 - 10 business days*

80.00€
Cay10010249-25 25 mg -

6 - 10 business days*

156.00€
Cay10010249-50 50 mg -

6 - 10 business days*

262.00€
 
The H series isoquinolinesulfonamide protein kinase (PK) inhibitors are widely used to block... more
Product information "H-8 (hydrochloride)"
The H series isoquinolinesulfonamide protein kinase (PK) inhibitors are widely used to block signaling pathways to elucidate mechanisms of cellular regulation and signal transduction. H-8, an isoquinolinesulfonamide protein kinase (PK) inhibitor, is a potent inhibitor of PKA and PKG and shows moderate inhibition for PKC and MLCK with Ki values of 1.2, 0.48, 15, and 68 µM, respectively. H-8 can disrupt transcriptional elongation by inhibiting cyclin C/Cdk8 and cyclin H/Cdk7/p36 CTD kinase activity with IC50 values of 47 and 6.2 µM, respectively.Formal Name: N-[2-(methylamino)ethyl]-5-isoquinolinesulfonamide, dihydrochloride. CAS Number: 113276-94-1. Synonyms: Protein Kinase Inhibitor H-8. Molecular Formula: C12H15N3O2S . 2HCl. Formula Weight: 338.3. Purity: >98%. Formulation: (Request formulation change), A crystalline solid. Solubility: DMF: 20 mg/ml, DMSO: 20 mg/ml, PBS (pH 7.2): 10 mg/ml. lambdamax: 217, 276, 324 nm. SMILES: CNCCNS(C1=CC=CC2=CN=CC=C21)(=O)=O.Cl.Cl. InChi Code: InChI=1S/C12H15N3O2S.2ClH/c1-13-7-8-15-18(16,17)12-4-2-3-10-9-14-6-5-11(10)12,,/h2-6,9,13,15H,7-8H2,1H3,2*1H. InChi Key: RJJLZYZEVNCZIW-UHFFFAOYSA-N.
Keywords: Protein Kinase Inhibitor H-8, N-[2-(methylamino)ethyl]-5-isoquinolinesulfonamide, dihydrochloride
Supplier: Cayman Chemical
Supplier-Nr: 10010249

Properties

Application: PKA inhibitor, PKG inhibitor
MW: 338.3 D
Formula: C12H15N3O2S . 2HCl
Purity: >98%
Format: Crystalline Solid

Database Information

CAS : 113276-94-1| Matching products

Handling & Safety

Storage: -20°C
Shipping: +20°C (International: -20°C)
Caution
Our products are for laboratory research use only: Not for administration to humans!
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