14 products were found matching "Cay16060"!

Guanosine 5'-triphosphate (GTP) acts as a substrate for the synthesis of RNA during the transcription process and the synthesis of DNA during DNA replication. It is generated by the citric acid cycle and provides a source of energy for protein synthesis and gluconeogenesis, activating substrates in metabolic...

PAF is a potent phospholipid mediator which exerts diverse biological actions by interaction with a G protein-coupled PAF receptor. The PAF receptor has been cloned from a number of species including human, rat, and guinea pig and is characterized as a 7-transmembrane receptor which induces phosphoinositol turnover...

Cytarabine (ara-C) is a nucleoside analog and prodrug form of the DNA polymerase inhibitor ara-CTP. It is triphosphorylated to ara-CTP by the successive actions of deoxycytidine kinase, deoxycytidylate kinase, and nucleoside diphosphate kinase. Ara-C inhibits proliferation of HL-60, ML-1, Raji, and Jurkat human...

Meropenem is a carbapenem antibiotic. It is active against clinical isolates of Gram-positive and Gram-negative bacteria in vitro, including S. pneumoniae, H. influenzae, N. gonorrhoeae, E. coli, P. aeruginosa, C. difficile, and methicillin-susceptible and -resistant S. aureus (MICs = =0.008-8 µg/ml). It is...

L-(+)-Cystathionine is a dipeptide formed by serine and homocysteine. Transsulfuration of methionine yields homocysteine, which combines with serine to form this precursor of cysteine. L-(+)-Cystathionine is largely expressed in the mammalian brain and deficiency can indicate the presence of metabolic disorders such...

(±)-Muscone is an odoriferous constituent of musk, a glandular secretion originally collected from the male musk deer, that has found use both in the composition of perfumes and in traditional Chinese medicine practices. (±)-Muscone has been shown to exhibit anti-inflammatory effects by reducing the expression of...

Progeria is a genetic disorder that results in the appearance of premature aging. Genetically, progeria is characterized by a mutation in lamin A, which results in misshapen cell nuclei and DNA damage. Remodelin is a 2-thiazolylhydrazone derivative that, at 10 µM, improves nuclear architecture, chromatin...

Arachidonoyl ethanolamide (AEA, Cay-90050), also known as anandamide, is an endogenous ligand of the cannabinoid receptors. AEA is metabolized by fatty acid amide hydrolase (FAAH) to give arachidonic acid (Cay-90010) and ethanolamine. ARN1203 is a fluorinated analog of AEA that serves as a substrate of FAAH (Km = 29...

Platelet-activating factor acetylhydrolase (PAF-AH) is a calcium-independent member of the phospholipase A2 (PLA2) family that hydrolyzes the acetyl group at the sn-2 position of PAF, a phospholipid mediator involved in a variety of biological activities. There are three types of PAF-AH: two intracellular forms,...

To be used in conjunction with Cayman's PAF receptor polyclonal antiserum (Catalog No. 160602) to block protein-antibody complex formation during analysis for the PAF receptor.Synonyms: Platelet-activating Factor Receptor. Formulation: (Request formulation change), 200 µg of peptide. Storage Buffer: 200 µl TBS, pH...

PGI synthase (PGIS) catalyzes the conversion of PGH2 to PGI2 (prostacyclin). Human lung PGIS is a 56 kDa protein. The cloned bovine and human enzymes contain 500 amino acids and have a calculated molecular mass of 56,629 and 57,103, respectively. There is 88% homology between human and bovine PGIS.Synonyms: PGI...

PAF is a potent phospholipid mediator which exerts diverse biological actions by interaction with a G protein-coupled PAF receptor. The PAF receptor has been cloned from a number of species including human, rat, and guinea pig and is characterized as a 7-transmembrane receptor which induces phosphoinositol turnover...