- Search results for Cay12090
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8 products were found matching "Cay12090"!
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Item number: Cay12090-500
Glimepiride is an inhibitor of sulfonylurea receptors (SURs) linked to the inwardly rectifying potassium channel (Kir6.2, IC50s = 3, 5.4, and 7.3 nM for SUR1/Kir6.2, SUR2A/Kir6.2, and SUR2B/Kir6.2, respectively, in Xenopus oocytes expressing the mouse receptor). It also induces intracellular insulin receptor (InsR)...
Keywords: | HOE 490,... |
Application: | Sulfonylurea receptor 1 agonist, ATP-sensitive potassium (KATP) channel inhibitor |
CAS | 93479-97-1 |
MW: | 490.6 D |
From 66.00€
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Item number: Cay12092-50
Etoposide is a plant alkaloid and an inhibitor of topoisomerase II (IC50 = 60.3 µM). It inhibits proliferation of a variety of adenocarcinoma cells (IC50s = 0.005-12,200 µM) and human umbilical vein endothelial (HUVEC) cells (IC50 = 0.249 µM). It reduces tumor growth in an Ma human embryonal carcinoma mouse...
Keywords: | EPE, NSC 141540, VP-16-123,... |
Application: | DNA Topoisomerase II inhibitor, Apoptosis inducer |
CAS | 33419-42-0 |
MW: | 588.6 D |
From 27.00€
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Item number: Cay12097-10
Pazopanib is a multi-kinase inhibitor that inhibits the VEGF receptors VEGFR1, VEGFR2, and VEGFR3 (IC50s = 10, 30, and 47 nM, respectively, in a cell-free enzyme assay). It also inhibits PDGFRalpha, PDGFRbeta, and c-Kit (IC50s = 71, 84, and 74 nM, respectively, in a cell-free enzyme assay) as well as additional...
Keywords: | GSK-VEG10003, GW786034B, 5-[[4-[(2,3-dimethyl-2H-indazol-6-yl)methylamino]-2-pyrimidinyl]amino]-2-methyl-benzenesulfonamide |
Application: | Broad spectrum tyrosine kinase inhibitor |
CAS | 444731-52-6 |
MW: | 437.5 D |
From 37.00€
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Item number: Cay12099-10
The trimethoxyamphetamines (TMA) are a family of designer drugs developed on an amphetamine base. TMA-6, known more formally as 2,4,6-trimethoxyamphetamine, is a psychedelic hallucinogen which has appeared on the illicit drug market. Unlike amphetamines and cathinones, TMA-6 has no effect on the release or re-uptake...
Keywords: | TMA-6, 2,4,6-trimethoxy-alpha-methyl-benzeneethanamine, monohydrochloride |
Application: | Analytical reference standard, Psychedelic hallucinogen |
CAS | 23815-74-9 |
MW: | 261.7 D |
From 291.00€
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Item number: Cay12091-10
Epirubicin is a stereoisomer of the antitumor anthracycline doxorubicin (Cay-15007) that undergoes beta-glucuronidation, which partially detoxifies the dose-limiting side effects that are present with doxorubicin. Compared to doxorubicin, epirubicin is equally cytotoxic to HeLa cells (ID50s = 9 µM). When used either...
Keywords: | 4'-Epidoxorubicin,... |
Application: | Doxorubicin stereoisomer, Antitumor agent, Topoisomerase II inhibitor |
CAS | 56390-09-1 |
MW: | 580 D |
From 77.00€
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Item number: Cay12094-10
Janus-associated kinases (JAKs) are cytoplasmic tyrosine kinases that are required for activating the signaling of certain cytokines and growth factor receptors. A JAK2 gene fusion mutation, JAK2V617F, that causes unchecked activation of various growth factors and cytokines, has been linked to myeloproliferative...
Keywords: | A 154475.0, CEP-701, KT 5555, SP 924,... |
Application: | JAK2 inhibitor |
CAS | 111358-88-4 |
MW: | 439.5 D |
From 60.00€
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Item number: Cay12098-50
Tandutinib is a potent antagonist of platelet-derived growth factor receptor beta (PDGFRbeta), FLT3, and c-Kit (IC50 = 200, 220, and 170 nM, respectively). It less potently inhibits macrophage colony-stimulating factor 1 receptor (IC50 = 3.4 µM) and does not significantly inhibit other tyrosine or serine/threonine...
Keywords: | CT 53518, MLN518,... |
Application: | PDGFR-beta / Flt3 / c-Kit antagonist |
CAS | 387867-13-2 |
MW: | 562.7 D |
From 76.00€
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Item number: Cay12096-10
Mubritinib is a selective inhibitor of the human epidermal growth factor receptor 2 (HER2), inhibiting HER2 phosphorylation with an IC50 value of 6 nM. It is without effect on EGFR, FGFR, PDGFR, JAK1, Src, and Blk (IC50 > 25 µM). Mubritinib inhibits the proliferation of breast, bladder, kidney, and prostate cancer...
Keywords: | TAK-165, 1-[4-[4-[[2-[(1E)-2-[4-(trifluoromethyl)phenyl]ethenyl]-4-oxazolyl]methoxy]phenyl]butyl]-1H-1,2,3-triazole |
Application: | HER2 inhibitor |
CAS | 366017-09-6 |
MW: | 468.5 D |
From 53.00€
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