17 products were found matching "Cay10010410"!
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GW 848687X
Item number: Cay10010410-1
Four G protein-coupled receptors, EP1-4, initiate cellular signaling in response to prostaglandin PGE2. The receptor EP1 acts via Galphaq to evoke diverse effects, including renal vasoconstriction, bronchoconstriction, hyperalgesia, allodynia, gastric protection, hyperthermia, and sleep inhibition. GW 848687X is a...
| Keywords: | 6-[2-[5-chloro-2-[(2,4-digluorophenyl)methoxy]phenyl]-1-cyclopenten-1-yl]-2-pyridinecarboxylic acid |
| Application: | EP1 receptor antagonist |
| CAS | 612831-24-0 |
| MW: | 441.9 D |
From 119.00€
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ADHP
Item number: Cay10010469-10
ADHP is a highly sensitive, stable substrate for horseradish peroxidase (HRP) that enables selective detection of H2O2. This colorless, non-fluorescent reagent reacts with H2O2 to produce the fluorescent compound resorufin, which can be analyzed using an excitation wavelength of 520-550 nm and an emission wavelength...
| Keywords: | A 6550, ADHP, Amplex Red(R), 1-(3,7-dihydroxy-10H-phenoxazin-10-yl)-ethanone |
| Application: | HRP substrate |
| CAS | 119171-73-2 |
| MW: | 257.2 D |
From 34.00€
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SP600125
Item number: Cay10010466-10
SP6000125 is a pan-inhibitor of JNK (IC50s = 0.04, 0.04, and 0.09 µM for JNK1, -2, and -3, respectively). It is greater than 300-fold selective for these enzymes over a panel of 17 additional kinases at 10 µM. SP6000125 reduces LPS-induced production of IL-1beta, IL-8, and TNF-alpha in isolated human peripheral...
| Keywords: | 1PMV, NSC 75890, Pyrazolanthrone, anthra[1,9-cd]pyrazol-6(2H)-one |
| Application: | JNK inhibitor |
| CAS | 129-56-6 |
| MW: | 220.2 D |
From 60.00€
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KRP 203
Item number: Cay10010426-10
KRP 203 is a sphingosine-1-phosphate receptor 1 (S1P1) agonist. It selectively induces calcium mobilization in CHO-K1 cells expressing mouse S1P1 over mouse S1P3 and S1P4 (EC50s = 0.84, >1,000, and 9.61 nM, respectively). In vivo, KRP 203 (0.3 mg/kg) prevents the development of wasting syndrome, decreases diarrhea...
| Keywords: | Mocravimod (hydrochloride), 2-amino-2-[2-[2-chloro-4-[[3-(phenylmethoxy)phenyl]thio]phenyl]ethyl]-1,3-propanediol,... |
| Application: | S1P1 receptor agonist |
| CAS | 509088-69-1 |
| MW: | 480.4 D |
From 68.00€
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Nilotinib
Item number: Cay10010422-10
Nilotinib is an inhibitor of wild-type and mutant Bcr-Abl (IC50s = 15 and 9-400 nM, respectively). It is selective for wild-type and mutant Bcr-Abl over Src and LYN (IC50s = >5,000 nM for both). Nilotinib inhibits Bcr-Abl autophosphorylation and cell proliferation in Ba/F3 cells expressing wild-type or mutant...
| Keywords: | AMN107,... |
| Application: | Bcr inhibitor, Abl inhibitor |
| CAS | 641571-10-0 |
| MW: | 529.5 D |
From 34.00€
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CJ-42794
Item number: Cay10010428-10
Prostaglandin E2 (PGE2) activates four E prostanoid (EP) receptors, EP1-4. EP4 is a Gs protein-coupled receptor that, by elevating the second messenger cAMP, plays important roles in bone formation and resorption, cancer, and atherosclerosis. CJ-42794 is a selective antagonist of EP4 (Ki = 3.16 nM) that less...
| Keywords: | RQ-00015986, 4-[(1S)-1-[[5-chloro-2-(4-fluorophenoxy)benzoyl]amino]ethyl]-benzoic acid |
| Application: | EP4 receptor agonist |
| CAS | 847728-01-2 |
| MW: | 413.8 D |
From 72.00€
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Zaprinast
Item number: Cay10010421-10
The cyclic nucleotide second messenger guanosine 3'5'-cyclic monophosphate (cGMP) is an important mediator of signal transduction and hence a wide range of cellular processes. It can be generated by soluble guanylyl cyclase in response to binding of nitric oxide and degraded via members of the phosphodiesterase...
| Keywords: | 2-(o-Propoxyphenyl)-8-azapurin-6-one, M&B 22,948, 3,6-dihydro-5-(2-propoxyphenyl)-7H-1,2,3-triazolo[4,5-d]pyrimidin-7-one |
| Application: | PDE inhibitor |
| CAS | 37762-06-4 |
| MW: | 271.3 D |
From 38.00€
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CAY10571
Item number: Cay10010400-10
Pyridinylimidazoles, often termed CSAIDs, are a class of anti-inflammatory compounds that inhibit eicosanoid production and suppress the synthesis of cytokines in human monocytes. Because of its high specificity, one predominant pyridinylimidazole, SB203580, is frequently used to inhibit p38 MAPK, the tyrosine...
| Keywords: | 4-[5-(4-fluorophenyl)-2-[4-(methylsulfonyl)phenyl]-1H-imidazol-4-yl]-pyridine |
| Application: | p38 MAPK inhibitor |
| CAS | 152121-46-5 |
| MW: | 393.4 D |
From 64.00€
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15-keto-17-phenyl trinor Prostaglandin F2alpha ethyl amide
Item number: Cay10010405-10
Bimatoprost is the Allergan trade name for 17-phenyl trinor prostaglandin F2alpha ethyl amide (17-phenyl trinor PGF2alpha ethyl amide), an F-series PG analog which has been approved for use as an ocular hypotensive drug. Oxidation of the C-15 hydroxyl group produces 15-keto-17-phenyl trinor PGF2alpha ethyl amide....
| Keywords: | 15-keto-Bimatoprost, 17-phenyl trinor PGF2alpha ethyl amide,... |
| Application: | F-series PG analog |
| CAS | 1163135-96-3 |
| MW: | 413.5 D |
From 92.00€
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NS 304
Item number: Cay10010411-10
Prostaglandin I2 (PGI2) is a potent vasorelaxant and inhibitor of human platelet aggregation that mediates its actions by binding to a specific G protein-coupled receptor, the IP receptor, on the surface of endothelial cells and platelets. The IP receptor also participates in signal transduction of the pain...
| Keywords: | ACT-293987, Selexipag, 2-[4-[(5,6-diphenylpyrazinyl)(1-methylethyl)amino]butoxy]-N-(methylsulfonyl)-acetamide |
| Application: | IP receptor agonist |
| CAS | 475086-01-2 |
| MW: | 496.6 D |
From 61.00€
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MRE-269
Item number: Cay10010412-50
Prostacyclin (PGI2) is a potent vasorelaxant and inhibitor of platelet aggregation. It mediates its actions by binding to a specific G protein-coupled receptor, the IP receptor, on the surface of endothelial cells, arterial smooth muscle, and platelets. The IP receptor also participates in signal transduction of the...
| Keywords: | [4-[(5,6-diphenylpyrazinyl)(1-methylethyl)amino]butoxy]-acetic acid |
| Application: | IP receptor agonist |
| CAS | 475085-57-5 |
| MW: | 419.5 D |
From 48.00€
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15-Lipoxygenase Inhibitor 1
Item number: Cay10010468-10
15-Lipoxygenase inhibitor 1 is a 15-lipoxygenase (15-LO) inhibitor (IC50 = 18 µM). It scavenges DPPH (Cay-14805) radicals in a cell-free assay (IC50 = 69.6 µM).Formal Name: 4-methyl-2-(4-methylpiperazinyl)pyrimido[4,5-b]benzothiazine. CAS Number: 928853-86-5. Synonyms: 15-LO Inhibitor 1, 4-MMPB. Molecular Formula:...
| Keywords: | 15-LO Inhibitor 1, 4-methyl-2-(4-methylpiperazinyl)pyrimido[4,5-b]benzothiazine |
| Application: | 15-LO inhibitor |
| CAS | 928853-86-5 |
| MW: | 313.4 D |
From 43.00€
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