GW 627368X

GW 627368X
Item number Size Datasheet Manual SDS Delivery time Quantity Price
Cay10009162-1 1 mg -

6 - 10 business days*

80.00€
Cay10009162-5 5 mg -

6 - 10 business days*

339.00€
Cay10009162-10 10 mg -

6 - 10 business days*

600.00€
Cay10009162-25 25 mg -

6 - 10 business days*

1,311.00€
 
The effects of prostaglandin E2 (PGE2) are transduced by at least four distinct receptors... more
Product information "GW 627368X"
The effects of prostaglandin E2 (PGE2) are transduced by at least four distinct receptors designated EP1, EP2, EP3, and EP4. GW 627368X is a potent and selective competitive antagonist of the EP4 receptor with additional human TP receptor affinity. In competition radioligand bioassays, GW 627368X had affinity for human EP4 and TP receptors with Ki values of 100 nM and 158 nM, respectively. Affinity for all other human prostanoid receptors is >5.0 µM. In human washed platelets, GW 627368X produced 100% inhibition of U-46619 (EC100)-induced aggregation at a concentration of 10 µM.Formal Name: 4-(4,9-diethoxy-1,3-dihydro-1-oxo-2H-benz[f]isoindol-2-yl)-N-(phenylsulfonyl)-benzeneacetamide. CAS Number: 439288-66-1. Molecular Formula: C30H28N2O6S. Formula Weight: 544.6. Purity: >96%. Formulation: (Request formulation change), A crystalline solid. Solubility: DMF: 30 mg/ml, DMF:PBS (pH 7.2) (1:2): 0.3 mg/ml, DMSO: 10 mg/ml. lambdamax: 217, 229, 248, 295, 353 nm. SMILES: CCOc1c2C(=O)N(Cc2c(OCC)c2ccccc12)c1ccc(cc1)CC(=O)NS(=O)(=O)c1ccccc1. InChi Code: InChI=1S/C30H28N2O6S/c1-3-37-28-23-12-8-9-13-24(23)29(38-4-2)27-25(28)19-32(30(27)34)21-16-14-20(15-17-21)18-26(33)31-39(35,36)22-10-6-5-7-11-22/h5-17H,3-4,18-19H2,1-2H3,(H,31,33). InChi Key: XREWXJVMYAXCJV-UHFFFAOYSA-N.
Keywords: 4-(4,9-diethoxy-1,3-dihydro-1-oxo-2H-benz[f]isoindol-2-yl)-N-(phenylsulfonyl)-benzeneacetamide
Supplier: Cayman Chemical
Supplier-Nr: 10009162

Properties

Application: EP4 receptor antagonist
MW: 544.6 D
Formula: C30H28N2O6S
Purity: >96%
Format: Crystalline Solid

Database Information

CAS : 439288-66-1| Matching products

Handling & Safety

Storage: -20°C
Shipping: +20°C (International: -20°C)
Signal Word: Warning
GHS Hazard Pictograms:
H Phrases: H302, H315, H319, H335
P Phrases: P261, P264, P270, P271, P280, P301+310, P302+352, P304+340, P305+351+338, P312, P321, P330, P332+313, P337+313, P362+364, P403+233, P405, P501
Caution
Our products are for laboratory research use only: Not for administration to humans!
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