6 products were found matching "Cay16915"!

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GW 441756
GW 441756

Item number: Cay16915-5

The high affinity nerve growth factor (NGF) receptor, also known as NGF tyrosine kinase receptor A (TrkA), is involved in the development and maturation of the nervous system. Aberrant expression is associated with certain forms of cancer and congenital insensitivity to pain with anhidrosis. GW 441756 is a potent...
Keywords: 1,3-dihydro-3-[(1-methyl-1H-indol-3-yl)methylene]-2H-pyrrolo[3,2-b]pyridin-2-one
Application: TrkA inhibitor
CAS 504433-23-2
MW: 275.3 D
From 32.00€ *
Review
RAF265
RAF265

Item number: Cay16991-5

RAF265 is a dual inhibitor of mutant B-RafV600E and vascular endothelial growth factor receptor 2 (EC50s = 0.14 and 0.19 µM, respectively, in cell-based assays). It can also inhibit wild-type B-Raf, platelet-derived growth factor receptor, colony-stimulating factor 1R, RET, c-KIT, SRC, and STE20 with IC50 values...
Keywords: CHIR265,...
Application: B-Raf V600E / VEGFR2 inhibitor
CAS 927880-90-8
MW: 518.4 D
From 60.00€ *
Review
K145 (hydrochloride)
K145 (hydrochloride)

Item number: Cay11691-5

K145 is a selective inhibitor of sphingosine kinase 2 (SPHK2, Ki = 6.4 µM) with IC50 values of 4.3 and >10 µM for human recombinant SPHK2 and SPHK1, respectively. It inhibits SPHK2, but not SPHK1, activity in U937 cells when used at a concentration of 10 µM. In vivo, K145 (15 mg/kg, i.p.) inhibits tumor growth in a...
Keywords: 3-(2-aminoethyl)-5Z-[3-(4-butoxyphenyl)propylidene]-2,4-thiazolidinedione, monohydrochloride
Application: SphK2 inhibitor
CAS 1449240-68-9
MW: 384.9 D
From 43.00€ *
Review
RGFP966
RGFP966

Item number: Cay16917-5

HDAC3 is highly expressed in brain, and its activity has been associated with negative regulation of learning and memory processes. RGFP966 is a selective inhibitor of HDAC3 (IC50 = 0.08 µM) that does not affect other HDACs at concentrations up to 15 µM. At 10 mg/kg, RGFP966 can facilitate the extinction of...
Keywords: (2E)-N-(2-amino-4-fluorophenyl)-3-[1-(3-phenyl-2-propen-1-yl)-1H-pyrazol-4-yl]-2-propenamide
Application: HDAC3 inhibitor
CAS 1357389-11-7
MW: 362.4 D
From 42.00€ *
Review
BG45
BG45

Item number: Cay16918-5

BG45 is an HDAC class I inhibitor with selectivity for HDAC3 (IC50 = 289 nM). It inhibits HDAC1, HDAC2, and HDAC6 with greatly reduced potency (IC50s = 2, 2.2, and >20 µM, respectively). At concentrations up to 50 mg/kg, BG45 alone or in combination with bortezomib has been shown to dose-dependently inhibit tumor...
Keywords: N-(2-aminophenyl)-2-pyrazinecarboxamide
Application: HDAC3 inhibitor
CAS 926259-99-6
MW: 214.2 D
From 109.00€ *
Review
BRD73954
BRD73954

Item number: Cay16919-5

BRD73954 is a dual inhibitor of histone deacetylase 6 (HDAC6) and HDAC8 (IC50s = 36 and 120 nM, respectively). It is selective for HDAC6 and -8 over HDAC1-5, -7, and -9 (IC50s = 12, 9, 23, >33, >33, 13, and >33 µM, respectively). BRD73954 (10 µM) increases acetylation of alpha-tubulin, a known HDAC6 substrate, but...
Keywords: N1-hydroxy-N3-(2-phenylethyl)-1,3-benzenedicarboxamide
Application: HDAC6 / HDAC8 inhibitor
CAS 1440209-96-0
MW: 284.3 D
From 109.00€ *
Review