GSK-J1 (sodium salt)

GSK-J1 (sodium salt)
Item number Size Datasheet Manual SDS Delivery time Quantity Price
Cay12054-1 1 mg -

6 - 10 business days*

43.00€
Cay12054-5 5 mg -

6 - 10 business days*

156.00€
Cay12054-10 10 mg -

6 - 10 business days*

226.00€
Cay12054-50 50 mg -

6 - 10 business days*

1,016.00€
 
The histone H3 lysine 27 (H3K27) demethylase JMJD3 plays important roles in the transcriptional... more
Product information "GSK-J1 (sodium salt)"
The histone H3 lysine 27 (H3K27) demethylase JMJD3 plays important roles in the transcriptional regulation of cell differentiation, development, the inflammatory response, and cancer. GSK-J1 is a potent inhibitor of the H3K27 histone demethylases JMJD3 and UTX (IC50s = 18 and 56 µM, respectively as measured by mass spectrometry, IC50 = 60 nM in JMJD3 antibody-based assays). It is inactive against a panel of additional JMJ family demethylases, including several variants of JMJD2 and JMJD1 and, at concentrations up to 30 µM, has no effect on more than 100 different kinases or other unrelated proteins, including other chromatin-modifying enzymes such as histone deacetylases. Since the highly polar carboxylate group of GSK-J1 restricts its cellular permeability, a prodrug ethyl ester, GSK-J4 (Cay-12073) has also been developed. See the Structural Genomics Consortium (SGC) website for more information.Formal Name: N-[2-(2-pyridinyl)-6-(1,2,4,5-tetrahydro-3H-3-benzazepin-3-yl)-4-pyrimidinyl]-beta-alanine, monosodium salt. CAS Number: 1797832-71-3. Molecular Formula: C22H22N5O2 . Na. Formula Weight: 411.4. Purity: >95%. Formulation: (Request formulation change), A crystalline solid. Solubility: DMSO: Slightly soluble. lambdamax: 253 nm. SMILES: [O-]C(CCNC1=CC(N2CCC(C=CC=C3)=C3CC2)=NC(C4=CC=CC=N4)=N1)=O.[Na+]. InChi Code: InChI=1S/C22H23N5O2.Na/c28-21(29)8-12-24-19-15-20(26-22(25-19)18-7-3-4-11-23-18)27-13-9-16-5-1-2-6-17(16)10-14-27,/h1-7,11,15H,8-10,12-14H2,(H,28,29)(H,24,25,26),/q,+1/p-1. InChi Key: RAIROFAAPRKDPT-UHFFFAOYSA-M.
Keywords: N-[2-(2-pyridinyl)-6-(1,2,4,5-tetrahydro-3H-3-benzazepin-3-yl)-4-pyrimidinyl]-beta-alanine, monosodium salt
Supplier: Cayman Chemical
Supplier-Nr: 12054

Properties

Application: JMJD3 inhibitor
MW: 411.4 D
Formula: C22H22N5O2 . Na
Purity: >95%
Format: Crystalline Solid

Database Information

CAS : 1797832-71-3| Matching products
KEGG ID : K11448 | Matching products

Handling & Safety

Storage: -20°C
Shipping: +20°C (International: -20°C)
Caution
Our products are for laboratory research use only: Not for administration to humans!
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