Calphostin C is a metabolite of the fungus C. cladosporioides that specifically inhibits protein kinase C (PKC) (IC50 = 50 nM versus an IC50 > 50 µM for PKA) by competing at the binding site for diacylglycerol and phorbol esters. As a polycyclic hydrocarbon with strong absorbance in the visible and ultraviolet...

The anaphylatoxin C3a induces a range of responses by activating its G protein-coupled receptor, C3aR, resulting in calcium mobilization. SB 290157 is a non-peptide antagonist of C3aR, competitively blocking C3a binding with an IC50 value of 200 nM. It potently inhibits a wide variety of C3a-induced responses in...

Signal Transducers and Activators of Transcriptions (STATs) are a family of cytoplasmic latent transcription factors that are activated to regulate gene expression in response to a large number of extracellular signaling polypeptides including cytokines, interferons, and growth factors. STAT5, which consists of two...

Bicyclomycin benzoate is an antibiotic produced by S. sapporonensis that inhibits Gram-negative bacteria, including E. coli, Klebsiella, Shigella, Salmonella, Citrobacter, E. cloacae, and the pathogenic group of Neisseria. It is inactive against Proteus, P. aeruginosa, and Gram-positive bacteria.Formal Name:...

5-(2-Aminopyridyl)amide oxime is a synthetic intermediate useful for pharmaceutical synthesis.Formal Name: 6-amino-N-hydroxy-3-pyridinecarboximidamide. CAS Number: 468068-28-2. Molecular Formula: C6H8N4O. Formula Weight: 152.2. Purity: >98%. Formulation: (Request formulation change), A crystalline solid. Solubility:...