Fumonisin B1

Fumonisin B1
Item number Size Datasheet Manual SDS Delivery time Quantity Price
Cay62580-1 1 mg -

6 - 10 business days*

98.00€
Cay62580-5 5 mg -

6 - 10 business days*

434.00€
Cay62580-10 10 mg -

6 - 10 business days*

722.00€
 
Fumonisin B1 (FB1) is a mycotoxin that has been found in F. moniliforme. It inhibits ceramide... more
Product information "Fumonisin B1"
Fumonisin B1 (FB1) is a mycotoxin that has been found in F. moniliforme. It inhibits ceramide synthase (IC50 = 0.1 µM for the rat liver enzyme). FB1 induces DNA fragmentation and apoptosis in CV-1 cells when used at concentrations of 5 and 25 µM, respectively. It is cytotoxic to primary rat hepatocytes and induces hepatocyte nodule formation, a marker of cancer initiation, in rats when administered at a dose of 500 mg/kg for 21 days. It has been detected in corn and corn-based foods and livestock feeds.Formal Name: (2R,2'R)-1,2,3-propanetricarboxylic acid, 1,1'-[(1S,2R)-1-[(2S,4R,9R,11S,12S)-12-amino-4,9,11-trihydroxy-2-methyltridecyl]-2-[(1R)-1-methylpentyl]-1,2-ethanediyl] ester. CAS Number: 116355-83-0. Synonyms: FB1. Molecular Formula: C34H59NO15. Formula Weight: 721.8. Purity: >95%. Formulation: (Request formulation change), A crystalline solid. Solubility: DMF: 5 mg/ml, DMSO: 5 mg/ml, Ethanol: 10 mg/ml, PBS pH 7.2: 1 mg/ml. SMILES: C[C@H](N)[C@@H](O)C[C@H](O)CCCC[C@@H](O)C[C@H](C)C[C@H](OC(C[C@H](C(O)=O)CC(O)=O)=O)[C@H](OC(C[C@H](C(O)=O)CC(O)=O)=O)[C@H](C)CCCC. InChi Code: InChI=1S/C34H59NO15/c1-5-6-9-20(3)32(50-31(44)17-23(34(47)48)15-29(41)42)27(49-30(43)16-22(33(45)46)14-28(39)40)13-19(2)12-24(36)10-7-8-11-25(37)18-26(38)21(4)35/h19-27,32,36-38H,5-18,35H2,1-4H3,(H,39,40)(H,41,42)(H,45,46)(H,47,48)/t19-,20+,21-,22?,2. InChi Key: UVBUBMSSQKOIBE-CPRNOWDYSA-N.
Keywords: FB1, (2R,2'R)-1,2,3-propanetricarboxylic acid, 1,1'-[(1S,2R)-1-[(2S,4R,9R,11S,12S)-12-amino-4,9,11-trihydroxy-2-methyltridecyl]-2-[(1R)-1-methylpentyl]-1,2-ethanediyl] ester
Supplier: Cayman Chemical
Supplier-Nr: 62580

Properties

Application: Ceramide synthase inhibitor
MW: 721.8 D
Formula: C34H59NO15
Purity: >95%
Format: Crystalline Solid

Database Information

CAS : 116355-83-0| Matching products
KEGG ID : K04710 | Matching products

Handling & Safety

Storage: -20°C
Shipping: +20°C (International: -20°C)
Signal Word: Warning
GHS Hazard Pictograms:
H Phrases: H351
P Phrases: P201, P202, P280, P308+313, P405, P501
Caution
Our products are for laboratory research use only: Not for administration to humans!
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