Adhesion of fractalkine to the CX3CR1 receptor triggers the chemotaxis and adhesion of leukocytes, including T cells, monocytes and NK cells and studies have suggested that fractalkine is involved in the regulation of brain microglia during neuroinflammatory processes (1) and may play a role in dendritic...

CX3CL1, also known as fractalkine. CX3CL1 has a unique CX3C cysteine motif near the amino terminus and is the first member of a fourth branch of the chemokine superfamily. Unlike other known chemokines, CX3CL1 is a type 1 membrane protein containing a chemokine domain tethered on a long mucin like stalk. It is...

AHP453B is specific for human fractalkine, otherwise known as CX3CL1, a 397aa CX3C chemokine which signals through the CX3CR1 receptor and is expressed by various tissues including the brain, testis, lung, heart, kidney, colon and skeletal muscle. Adhesion of fractalkine to the CX3CR1 receptor triggers the...