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The soluble form is chemotactic for T-cells and monocytes, but not for neutrophils. The... more
Product information "Fractalkine (CX3CL1), His Tag, human recombinant (rHuCX3CL1-His)"
The soluble form is chemotactic for T-cells and monocytes, but not for neutrophils. The membrane-bound form promotes adhesion of those leukocytes to endothelial cells. May play a role in regulating leukocyte adhesion and migration processes at the endothelium. Binds to CX3CR1. (www.uniprot.org) Human recombinant Fractalkine produced in E.coli is a single, non-glycosylated, polypeptide chain containing 76 amino acids (fragment 25-100) having a total molecular mass of 17.5kDa and fused with a 4.5kDa amino-terminal hexahistidine tag. Fractalkine soluble form is chemotactic for t-cells and monocytes, but not for neutrophils. Fractalkine membrane-bound form promotes adhesion of those leukocytes to endothelial cells. Fractalkine regulates leukocyte adhesion and migration processes at the endothelium and binds to CX3CR1. Natural human Fractalkine is produced as a long protein (373-amino acid) with an extended mucin-like stalk and a chemokine domain on top. The mucin-like stalk permits it to bind to the cell surface. Fractalkine gene is located on human chromosome 16 along with some CC chemokines known as CCL17 and CCL22.
Keywords: | Fractalkine, CX3CL1, Neurotactin, CX3C membrane-anchored chemokine, Small inducible cytokine D1, NTN, NTT, CXC3, CXC3C, SCYD1, ABCD-3, C3Xkine |
Supplier: | Biomol GmbH |
Supplier-Nr: | 97254 |
Properties
Application: | Bioassay |
Conjugate: | No |
Host: | E.coli |
Species reactivity: | human |
Purity: | >95% |
Format: | Purified |
Database Information
KEGG ID : | K05508 | Matching products |
UniProt ID : | P78423 | Matching products |
Handling & Safety
Storage: | -20°C |
Shipping: | +4°C (International: +4°C) |
Caution
Our products are for laboratory research use only: Not for administration to humans!
Our products are for laboratory research use only: Not for administration to humans!
Information about the product reference will follow.
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