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Fluvoxamine is a selective serotonin reuptake inhibitor (SSRI). It selectively inhibits reuptake of serotonin over norepinephrine reuptake in rat hypothalamic synaptosomes (Kis = 6.2 and 1,100 nM, respectively). Fluvoxamine (10 mg/kg) reduces immobility time in the forced swim test in mice, an effect that can be blocked by the sigma-1 (sigma1) receptor antagonist BD 1047 (Cay-22928). It also reduces marble-burying behavior in the marble-burying test in mice when administered at a dose of 45 mg/kg, indicating anxiolytic- or reduced obsessive compulsive-like behaviors. Formulations containing fluvoxamine have been used in the treatment of obsessive compulsive disorder and social anxiety disorder.Formal Name: (1E)-5-methoxy-1-[4-(trifluoromethyl)phenyl]-1-pentanone O-(2-aminoethyl)oxime, 2Z-butenedioate. CAS Number: 61718-82-9. Synonyms: DU-23000, MK-264, NSC 309469. Molecular Formula: C15H21F3N2O2 . C4H4O4. Formula Weight: 434.4. Purity: >95%. Formulation: (Request formulation change), A crystalline solid. Solubility: DMF: 30 mg/ml, DMSO: 30 mg/ml, Ethanol: 25 mg/ml, PBS (pH 7.2): 5 mg/ml. lambdamax: 253 nm. SMILES: COCCCC/C(C1=CC=C(C(F)(F)F)C=C1)=N\OCCN.OC(/C=C\C(O)=O)=O. InChi Code: InChI=1S/C15H21F3N2O2.C4H4O4/c1-21-10-3-2-4-14(20-22-11-9-19)12-5-7-13(8-6-12)15(16,17)18,5-3(6)1-2-4(7)8/h5-8H,2-4,9-11,19H2,1H3,1-2H,(H,5,6)(H,7,8)/b20-14+,2-1-. InChi Key: LFMYNZPAVPMEGP-PIDGMYBPSA-N.
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