Fibroblast Growth Factor-4, human recombinant (rHuFGF-4)

Recombinant human FGF4 produced in E.coli is a single, non-glycosylated, polypeptide chain containing 177 amino acids (31-206) and having a molecular mass of 19kDa. FGF4 holds s comprehensive mitogenic and cell survival activities and takes part in a range of biological processes including embryonic development, cell growth, morphogenesis, tissue repair, tumor growth and invasion. FGF4 possess oncogenic transforming activity. FGF4 and FGF3, oncogenic growth factors are localized on chromosome 11. Co-amplification of both factors was found in several kinds of human tumors. FGF4 functions in bone morphogenesis and limb development through the sonic hedgehog (SHH) signaling pathway.