Fibroblast Growth Factor-21 (FGF21), bovine recombinant (rbFGF-21)

Fibroblast Growth Factor-21 (FGF21), bovine recombinant (rbFGF-21)
Item number Size Datasheet Manual SDS Delivery time Quantity Price
97271.2 2 µg - -

3 - 10 business days*

94.00€
97271.10 10 µg - -

3 - 10 business days*

208.00€
97271.1 1 mg - -

3 - 10 business days*

7,571.00€
 
Bovine recombinant Fibroblast Growth Factor -21 produced in E.coli is a single, non-glycosylated,... more
Product information "Fibroblast Growth Factor-21 (FGF21), bovine recombinant (rbFGF-21)"
Bovine recombinant Fibroblast Growth Factor -21 produced in E.coli is a single, non-glycosylated, polypeptide chain containing 182 amino acids and having a molecular weight of 19.5 kDa. The FGFs are a family of more than 20 small (approx. 17?26 kDa) secreted peptides. The initial characterization of these proteins focused on their ability to stimulate fibroblast proliferation. This mitogenic activity was mediated through FGF receptors (FGFRs) 1, 2, or 3. A fourth closely related tyrosine kinase receptor (FGFR4) was able to bind the FGFs but did not lead to a mitogenic response. FGFs modulate cellular activity via at least 5 distinct subfamilies of high-affinity FGF receptors (FGFRs). There is growing evidence that FGFRs can be important for regulation of glucose and lipid homeostasis. FGFR-2 appears to be a key molecule during pancreatic development. Moreover, FGFR-4 has been implicated in cholesterol metabolism and bile acid synthesis. FGF-19, has been shown to cause resistance to diet-induced obesity and insulin desensitization and to improve insulin, glucose, and lipid profiles in diabetic rodents. Since these effects, at least in part, are mediated through the observed changes in metabolic rates, FGF-19 can be considered as a regulator of energy expenditure.
Keywords: Fibroblast growth factor 21, FGF-21, FGF21
Supplier: Biomol GmbH
Supplier-Nr: 97271

Properties

Application: Bioassay
Conjugate: No
Host: E.coli
Species reactivity: bovine
MW: 19500 D
Purity: >98%
Format: Purified

Database Information

KEGG ID : K22429 | Matching products
UniProt ID : E1BDA6 | Matching products

Handling & Safety

Storage: -20°C
Shipping: +4°C (International: +4°C)
Caution
Our products are for laboratory research use only: Not for administration to humans!
You will get a certificate here
or to request a certificate of analysis.
Read, write and discuss reviews... more
Customer review for "Fibroblast Growth Factor-21 (FGF21), bovine recombinant (rbFGF-21)"
Write a review
or to review a product.
Viewed