Fibroblast Growth Factor-19 (FGF19), human recombinant (rHuFGF19)

Fibroblast Growth Factor-19 (FGF19), human recombinant (rHuFGF19)
Item number Size Datasheet Manual SDS Delivery time Quantity Price
97315.5 5 µg - -

3 - 10 business days*

94.00€
97315.25 25 µg - -

3 - 10 business days*

208.00€
97315.1 1 mg - -

3 - 10 business days*

3,952.00€
 
Involved in the suppression of bile acid biosynthesis through down-regulation of CYP7A1... more
Product information "Fibroblast Growth Factor-19 (FGF19), human recombinant (rHuFGF19)"
Involved in the suppression of bile acid biosynthesis through down-regulation of CYP7A1 expression, following positive regulation of the JNK and ERK1/2 cascades. Stimulates glucose uptake in adipocytes. Activity requires the presence of KLB. (www.uniprot.org) Human recombinant FGF19 produced in E.coli is a single, non-glycosylated, polypeptide chain containing 195 amino acids and having a molecular mass of 21.8 kDa. The FGFs are a family of more than 20 small (approx. 17?26 kDa) secreted peptides. The initial characterization of these proteins focused on their ability to stimulate fibroblast proliferation. This mitogenic activity was mediated through FGF receptors (FGFRs) 1, 2, or 3. A fourth closely related tyrosine kinase receptor (FGFR4) was able to bind the FGFs but did not lead to a mitogenic response. FGFs modulate cellular activity via at least 5 distinct subfamilies of high-affinity FGF receptors (FGFRs). FGF-19, has been shown to cause resistance to diet-induced obesity and insulin desensitization and to improve insulin, glucose, and lipid profiles in diabetic rodents. Since these effects, at least in part, are mediated through the observed changes in metabolic rates, FGF-19 can be considered as a regulator of energy expenditure. FGF-21 is preferentially expressed in liver, but an exact knowledge of FGF-21 bioactivity and its mode of action have been lacking to date. FGF-21 is a potent activator of glucose uptake on adipocytes, protects animals from diet-induced obesity when overexpressed in transgenic mice, and lowers blood glucose and triglyceride levels when therapeutically administered to diabetic rodents.
Keywords: Fibroblast growth factor 19, FGF-19, FGF19
Supplier: Biomol GmbH
Supplier-Nr: 97315

Properties

Application: Cell culture
Conjugate: No
Host: E.coli
Species reactivity: human
MW: 21800 D
Purity: >90%
Format: Purified

Database Information

KEGG ID : K22603 | Matching products
UniProt ID : O95750 | Matching products

Handling & Safety

Storage: -20°C
Shipping: +4°C (International: +4°C)
Caution
Our products are for laboratory research use only: Not for administration to humans!
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