Kontakt 0800-2466651 DE | EN Merkliste Login | REGISTRIEREN Warenkorb
Reset
Suche
zurück

Fibroblast Growth Factor-19 (FGF19), human recombinant (rHuFGF19)

ART NR.: 97315.5 (5 µg)
97315.25 (25 µg)
97315.1 (1 mg)

Hersteller: Biomol GmbH

Datenblatt

Anwendungen: Cell culture

Exprimiert in: E.coli

Ursprungs-Art: human

MW: 21.800 D

Reinheit: >90%

Format: purified

Lagerung: -20°C

Versand: +4°C

UniProt ID: O95750 | Suche mit UniProt ID

KEGG ID: K04358 | Suche mit KEGG ID

Schlagworte: Fibroblast growth factor 19, FGF-19, FGF19

97315.5

5 µg

76 €

97315.25

25 µg

197 €

97315.1

1 mg

Größe wählen:
In Warenkorb aufnehmen


Bemerkungen: Involved in the suppression of bile acid biosynthesis through down-regulation of CYP7A1 expression, following positive regulation of the JNK and ERK1/2 cascades. Stimulates glucose uptake in adipocytes. Activity requires the presence of KLB. (www.uniprot.org) Human recombinant FGF19 produced in E.coli is a single, non-glycosylated, polypeptide chain containing 195 amino acids and having a molecular mass of 21.8 kDa. The FGFs are a family of more than 20 small (approx. 17?26 kDa) secreted peptides. The initial characterization of these proteins focused on their ability to stimulate fibroblast proliferation. This mitogenic activity was mediated through FGF receptors (FGFRs) 1, 2, or 3. A fourth closely related tyrosine kinase receptor (FGFR4) was able to bind the FGFs but did not lead to a mitogenic response. FGFs modulate cellular activity via at least 5 distinct subfamilies of high-affinity FGF receptors (FGFRs). FGF-19, has been shown to cause resistance to diet-induced obesity and insulin desensitization and to improve insulin, glucose, and lipid profiles in diabetic rodents. Since these effects, at least in part, are mediated through the observed changes in metabolic rates, FGF-19 can be considered as a regulator of energy expenditure. FGF-21 is preferentially expressed in liver, but an exact knowledge of FGF-21 bioactivity and its mode of action have been lacking to date. FGF-21 is a potent activator of glucose uptake on adipocytes, protects animals from diet-induced obesity when overexpressed in transgenic mice, and lowers blood glucose and triglyceride levels when therapeutically administered to diabetic rodents.

Die Preise verstehen sich exkl. Versandkosten, eventuell anfallender Kühlmittelpauschale sowie der jeweils geltenden Mehrwertsteuer.


Obesity and Diabetes ResearchPGRN - A Multifaceted BiomarkerAdiponectin

Stem Cell BiologyMouse ClusterinToll-Like Receptors Products alle Treffer anzeigen (11 INFOS)

 


Forschungsprodukte im Fokus
 
Produkte
Service
Company
€ 10 Gutschein sichern