Detection Type: Colorimetric. Assay Type: Sandwich. Sample Type: Cell Lysate. Sensitivity: 50pg/ml. Range: 0.156 to 10ng/ml. FTO (Fat mass-and obesity-associated gene) was discovered as a responsible gene causing the mouse 'fused toes' mutation. Studies using wildtype mice indicated that Fto mRNA is most abundant in the brain, particularly in hypothalamic nuclei governing energy balance, and that Fto mRNA levels in the arcuate nucleus are regulated by feeding and fasting. An association between FTO genotype and type 2 diabetes has been confirmed.The presence of the FTO rs9939609 Aallele was found to be positively correlated with other symptoms of the metabolic syndrome, including higher fasting insulin, glucose, and triglycerides, and lower HDL-cholesterol.
Datenblatt ansehen
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Kat #: AG-45A-0025TP-KI01
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UniProt ID: Q9C0B1 (Protein knowledgebase)
Schlagworte:
Fat Mass and Obesity-associated Protein, FATSO
Figure legend: Datenblatt ansehen
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