7 products were found matching "Cay10011667"!

Soluble epoxide hydrolase (sEH) is a member of the alpha/beta-hydrolase fold enzyme family that catalyzes the hydrolysis of bioactive fatty acid epoxides to inactive vicinal diols. It is a homodimer in which each subunit is composed of two domains, a C-terminal epoxide hydrolase domain and an N-terminal phosphatase...

FTI-276 is a CAAX peptidomimetic inhibitor of farnesyltransferase (FTase, IC50 = 500 pM). It contains the C-terminal CAAX sequence, Cys-Val-Iso-Met (CVIM), of K-Ras4B, a form of Ras that is commonly mutated in human cancers, and is selective for FTase over geranylgeranyltransferase I (GGTase I, IC50 = 50 nM). It...

Buphedrone is a substituted cathinone, analogous to methcathinone, which has been identified in products that are sold as stimulants. 4-methyl-N-Methylbuphedrone (hydrochloride) is a para-methyl analog of buphedrone with an aminomethyl addition. Its biological and toxicological properties are not known. This product...

Formulation: 50 µl of human recombinant HDAC1.

Soluble epoxide hydrolase (sEH) catalyzes the hydrolysis of exogenous and endogenous epoxides to vicinal diols. Endogenous substrates for sEH include epoxyeicosatrienoic acids (EETs) which exhibit vasodialatory and anti-inflammatory activity. Small molecule inhibitors of sEH may therefore hold promise as...

Ac-DEVD-CHO is a potent inhibitor of the Group II caspases, caspase-3 and caspase-7 (Kis = 0.23 and 1.6 nM, respectively). Notably, it also inhibits other caspases (Kis = 18, 1710, 132, 205, 31, 0.92, 60, and 12 nM for caspases-1, -2, -4, -5, -6, -8, -9, and -10, respectively). Caspase inhibitors in the aldehyde...

ST1535 is an adenosine A2A receptor antagonist. It is selective for adenosine A2A over A1 receptors (Kis = 2.3 and 107 nM, respectively, in radioligand binding assays). ST1535 inhibits agonist-induced production of cAMP in CHO cells expressing adenosine A2A receptors (IC50 = 353 nM). In vivo, ST1535 (10 and 20...