FNDC5:Fc (human) (rec.)

FNDC5:Fc (human) (rec.)
%
Item number Size Datasheet Manual SDS Delivery time Quantity Discount Price
AG-40B-0153-C010 10 µg -

3 - 9 business days*

10 %
286.00€
257.40€
AG-40B-0153-3010 30 µg (3 x 10 µg) -

3 - 9 business days*

10 %
572.00€
514.80€
 
FNDC5 (extracellular domain) (human, aa 32-152 / mouse, aa 29-149) is fused at the C-terminus to... more
Product information "FNDC5:Fc (human) (rec.)"
FNDC5 (extracellular domain) (human, aa 32-152 / mouse, aa 29-149) is fused at the C-terminus to the Fc portion of human IgG1. FNDC5 (extracellular domain) has 100% identity between mouse, rat and human. Endotoxin Content: <0.01EU/?g purified protein (LAL test, Lonza). Irisin is a recently described exercise-induced hormone secreted by skeletal muscle in mice and humans. Irisin activates beige fat cells (beige cells have a gene expression pattern distinct from either white or brown fat and are preferentially sensitive to the polypeptide hormone Irisin). Irisin is cleaved from the type I membrane protein FNDC5 and improves systemic metabolism by increasing energy expenditure. The membrane receptor FNDC5 can be cleaved by an unknown protease to release the Irisin protein (aa 32-143 for human) and potentially also the FNDC5 (extracellular domain, aa 32-153 for human). Human Irisin: Contrary to mouse, may not be involved in the beneficial effects of muscular exercise, nor in the induction of browning of human white adipose tissue. [The Uniprot Consortium]
Keywords: FNDC5, FRCP2, Fibronectin Type III Domain-containing Protein 5, Fibronectin Type III Repeat-containing Protein 2
Supplier: AdipoGen Life Sciences
Supplier-Nr: AG-40B-0153

Properties

Application: Cell culture
Conjugate: No
Host: Human cells
Species reactivity: human, mouse, rat
MW: 52 kD
Purity: >95%
Format: Lyophilized

Database Information

UniProt ID : Q8NAU1 | Matching products
Gene ID GeneID 252995 | Matching products

Handling & Safety

Storage: -20°C
Shipping: +4°C (International: +4°C)
Caution
Our products are for laboratory research use only: Not for administration to humans!
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