Cookie preferences
This website uses cookies, which are necessary for the technical operation of the website and are always set. Other cookies, which increase the comfort when using this website, are used for direct advertising or to facilitate interaction with other websites and social networks, are only set with your consent.
Configuration
Technically required
These cookies are necessary for the basic functions of the shop.
"Allow all cookies" cookie
"Decline all cookies" cookie
CSRF token
Cookie preferences
Currency change
Customer-specific caching
FACT-Finder tracking
Individual prices
Selected shop
Session
Comfort functions
These cookies are used to make the shopping experience even more appealing, for example for the recognition of the visitor.
Note
Show the facebook fanpage in the right blod sidebar
Statistics & Tracking
Affiliate program
Conversion and usertracking via Google Tag Manager
Track device being used
Peroxisome proliferator-activated receptor gamma (PPARgamma) isoforms heterodimerize with... more
Product information "FMOC-L-Leucine"
Peroxisome proliferator-activated receptor gamma (PPARgamma) isoforms heterodimerize with retinoic X receptors to modulate gene expression related to adipocyte differentiation, fatty acid uptake and storage, and glucose metabolism. Natural agonists of PPARgamma include fatty acids (e.g., linoleic acid and 15-deoxy-Delta12,14-prostaglandin J2), while thiazolidinediones (e.g., rosiglitazone and pioglitazone) are potent synthetic agonists. Fmoc-L-leucine is a partial agonist of PPARgamma. It activates PPARgamma with a lower potency (Ki = 15 versus 0.035 µM) but a similar maximal efficacy compared to rosiglitazone. Fmoc-L-leucine improves insulin resistance in normal, diet-induced glucose-intolerant and in diabetic db/db mice, yet has reduced adipogenic activity. As a result, it is classified as a selective PPARgamma modulator (SPPARM), capable of producing insulin-sensitizing effects while minimizing side effects associated with full agonists.Formal Name: N-[(9H-fluoren-9-ylmethoxy)carbonyl]-L-leucine. CAS Number: 35661-60-0. Synonyms: Fmoc-Leu, NPC 15199, NSC 334290. Molecular Formula: C21H23NO4. Formula Weight: 353.4. Purity: >98%. Formulation: (Request formulation change), A crystalline solid. Solubility: DMF: 30 mg/ml, DMSO: 30 mg/ml, Ethanol: 30 mg/ml, Ethanol:PBS (pH 7.2) (1:1): 0.5 mg/ml. lambdamax: 206, 265, 289, 300 nm. SMILES: CC(C)C[C@H](NC(=O)OCC1c2ccccc2c2ccccc12)C(=O)O. InChi Code: InChI=1S/C21H23NO4/c1-13(2)11-19(20(23)24)22-21(25)26-12-18-16-9-5-3-7-14(16)15-8-4-6-10-17(15)18/h3-10,13,18-19H,11-12H2,1-2H3,(H,22,25)(H,23,24). InChi Key: CBPJQFCAFFNICX-UHFFFAOYSA-N.
Keywords: | FMOC-Leu, NPC 15199, NSC 334290, N-[(9H-fluoren-9-ylmethoxy)carbonyl]-L-leucine |
Supplier: | Cayman Chemical |
Supplier-Nr: | 10004888 |
Properties
Application: | PPARgamma modulator |
MW: | 353.4 D |
Formula: | C21H23NO4 |
Purity: | >98% |
Format: | Crystalline Solid |
Database Information
CAS : | 35661-60-0| Matching products |
KEGG ID : | K08530 | Matching products |
Handling & Safety
Storage: | +20°C |
Shipping: | +20°C (International: +20°C) |
Caution
Our products are for laboratory research use only: Not for administration to humans!
Our products are for laboratory research use only: Not for administration to humans!
Information about the product reference will follow.
more
You will get a certificate here
Viewed