FMOC-L-Leucine

FMOC-L-Leucine
Item number Size Datasheet Manual SDS Delivery time Quantity Price
Cay10004888-25 25 g -

6 - 10 business days*

27.00€
Cay10004888-50 50 g -

6 - 10 business days*

50.00€
Cay10004888-100 100 g -

6 - 10 business days*

90.00€
 
Peroxisome proliferator-activated receptor gamma (PPARgamma) isoforms heterodimerize with... more
Product information "FMOC-L-Leucine"
Peroxisome proliferator-activated receptor gamma (PPARgamma) isoforms heterodimerize with retinoic X receptors to modulate gene expression related to adipocyte differentiation, fatty acid uptake and storage, and glucose metabolism. Natural agonists of PPARgamma include fatty acids (e.g., linoleic acid and 15-deoxy-Delta12,14-prostaglandin J2), while thiazolidinediones (e.g., rosiglitazone and pioglitazone) are potent synthetic agonists. Fmoc-L-leucine is a partial agonist of PPARgamma. It activates PPARgamma with a lower potency (Ki = 15 versus 0.035 µM) but a similar maximal efficacy compared to rosiglitazone. Fmoc-L-leucine improves insulin resistance in normal, diet-induced glucose-intolerant and in diabetic db/db mice, yet has reduced adipogenic activity. As a result, it is classified as a selective PPARgamma modulator (SPPARM), capable of producing insulin-sensitizing effects while minimizing side effects associated with full agonists.Formal Name: N-[(9H-fluoren-9-ylmethoxy)carbonyl]-L-leucine. CAS Number: 35661-60-0. Synonyms: Fmoc-Leu, NPC 15199, NSC 334290. Molecular Formula: C21H23NO4. Formula Weight: 353.4. Purity: >98%. Formulation: (Request formulation change), A crystalline solid. Solubility: DMF: 30 mg/ml, DMSO: 30 mg/ml, Ethanol: 30 mg/ml, Ethanol:PBS (pH 7.2) (1:1): 0.5 mg/ml. lambdamax: 206, 265, 289, 300 nm. SMILES: CC(C)C[C@H](NC(=O)OCC1c2ccccc2c2ccccc12)C(=O)O. InChi Code: InChI=1S/C21H23NO4/c1-13(2)11-19(20(23)24)22-21(25)26-12-18-16-9-5-3-7-14(16)15-8-4-6-10-17(15)18/h3-10,13,18-19H,11-12H2,1-2H3,(H,22,25)(H,23,24). InChi Key: CBPJQFCAFFNICX-UHFFFAOYSA-N.
Keywords: FMOC-Leu, NPC 15199, NSC 334290, N-[(9H-fluoren-9-ylmethoxy)carbonyl]-L-leucine
Supplier: Cayman Chemical
Supplier-Nr: 10004888

Properties

Application: PPARgamma modulator
MW: 353.4 D
Formula: C21H23NO4
Purity: >98%
Format: Crystalline Solid

Database Information

CAS : 35661-60-0| Matching products
KEGG ID : K08530 | Matching products

Handling & Safety

Storage: +20°C
Shipping: +20°C (International: +20°C)
Caution
Our products are for laboratory research use only: Not for administration to humans!
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