2 products were found matching "Cay13287-10"!
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FK-866
Item number: Cay13287-1
FK-866 is a highly specific non-competitive inhibitor of Nampt (Ki = 0.4 nM), causing gradual NAD+ depletion. In HepG2 human liver carcinoma cells, NAD+ depletion by FK-866 directs delayed cell death by apoptosis (IC50 = ~1 nM). In normal human smooth muscle cells, FK-866 causes premature senescence, an effect that...
| Keywords: | K 22.175, N-[4-(1-benzoyl-4-piperidinyl)butyl]-3-(3-pyridinyl)-2E-propenamide |
| Application: | NAMPT inhibitor |
| CAS | 658084-64-1 |
| MW: | 391.5 D |
From 35.00€
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Panobinostat
Item number: Cay13280-10
Panobinostat is a pan-inhibitor of histone deacetylases (HDACs, Kis = 0.6-31 nM for HDAC1-11). It inhibits growth in a panel of 37 human or mouse lung cancer cell lines, including small cell lung cancer (SCLC), non-small cell lung cancer (NSCLC), and mesothelioma cells (IC50s = 4-175, 5-310, and 5-470 nM,...
| Keywords: | LBH-589, (2E)-N-hydroxy-3-[4-[[[2-(2-methyl-1H-indol-3-yl)ethyl]amino]methyl]phenyl]-2-propenamide |
| Application: | HDAC inhibitor |
| CAS | 404950-80-7 |
| MW: | 349.4 D |
From 39.00€
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